none8siMechanochemical reaction of solid piracetam with the inorganic salts LiCl and LiBr yields ionic co-crystals which are also co-drugs, characterized by markedly different thermal properties with respect to pure components, also depending on the method for preparation and/or conditions of measurements; single crystal and powder X-ray diffraction at variable temperatures, DSC, TGA, hot stage microscopy (HSM) and intrinsic dissolution rate have been used to fully characterize the solid products.mixedD. Braga; F. Grepioni; L. Maini; D. Capucci; S. Nanna; J. Wouters; L. Aerts; L. QueréD. Braga; F. Grepioni; L. Maini; D. Capucci; S. Nanna; J. Wouters; L. Aerts; L. Quer
Approximately 40% of newly synthesized drugs are not able to enter market due to biopharmaceutical i...
Co-crystal screening was applied under the assumption that two molecules having relatively similar c...
Current United States Food and Drug Administration (FDA)-approved lithium salts are plagued with a n...
Grinding of solid brivaracetam (BRV) and seletracetam (SEL) with inorganic lithium salts yields orig...
Ionic co-crystals (ICCs) are constituted of inorganic salts and organic molecules. These crystals co...
Ionic co-crystals (ICCs) are constituted of inorganic salts and organic molecules. These crystals co...
Mechanochemical and solution based reactions of solid brivaracetam (BRV) and seletracetam (SEL), an...
In this study, we aim to develop a robust crystallization process for the ionic cocrystal between pi...
Co-crystal screening was applied under the assumption that two molecules having relatively similar c...
Combining APIs with specific molecules in a single crystal form shows potential during the developme...
Current lithium drugs are plagued with a narrow therapeutic window and tend to be hygroscopic. Howev...
peer-reviewedPharmaceutical cocrystals are long known but relatively understudied class of compounds...
(FDA)-approved lithium salts are plagued with a narrow therapeutic window. Recent attempts to find a...
In this highlight, the reasons for the widespread interest generated by ionic co-crystals, namely th...
The crystallisation of an active pharmaceutical ingredient (API) is a fundamental step in the manufa...
Approximately 40% of newly synthesized drugs are not able to enter market due to biopharmaceutical i...
Co-crystal screening was applied under the assumption that two molecules having relatively similar c...
Current United States Food and Drug Administration (FDA)-approved lithium salts are plagued with a n...
Grinding of solid brivaracetam (BRV) and seletracetam (SEL) with inorganic lithium salts yields orig...
Ionic co-crystals (ICCs) are constituted of inorganic salts and organic molecules. These crystals co...
Ionic co-crystals (ICCs) are constituted of inorganic salts and organic molecules. These crystals co...
Mechanochemical and solution based reactions of solid brivaracetam (BRV) and seletracetam (SEL), an...
In this study, we aim to develop a robust crystallization process for the ionic cocrystal between pi...
Co-crystal screening was applied under the assumption that two molecules having relatively similar c...
Combining APIs with specific molecules in a single crystal form shows potential during the developme...
Current lithium drugs are plagued with a narrow therapeutic window and tend to be hygroscopic. Howev...
peer-reviewedPharmaceutical cocrystals are long known but relatively understudied class of compounds...
(FDA)-approved lithium salts are plagued with a narrow therapeutic window. Recent attempts to find a...
In this highlight, the reasons for the widespread interest generated by ionic co-crystals, namely th...
The crystallisation of an active pharmaceutical ingredient (API) is a fundamental step in the manufa...
Approximately 40% of newly synthesized drugs are not able to enter market due to biopharmaceutical i...
Co-crystal screening was applied under the assumption that two molecules having relatively similar c...
Current United States Food and Drug Administration (FDA)-approved lithium salts are plagued with a n...