ORGAN-SPECIFIC BIOMARKERS OF HUMAN AGING: THE CASE OF LIVER

none20We faced the basic question on chronological versus biological age at tissue level in the context of organ transplant. By means of a comprehensive approach we analysed nuclear and mitochondrial DNA, mRNAs, microRNAs, proteins, including proteasome and immunoproteasome, obtained from liver biopsies of donors with different age (13-90 years) to identify biomarkers of biological age. Telomere length and specific miRNAs appear to be important biomarkers of liver aging. This research looks for the improvement of the graft management getting insights into donor- recipient age- mismatch effects.mixedM. Capri; F. Olivieri; D. Remondini; C. Lanzarini; R. Lazzarini; E. Bellavista; M. Martucci; A. Santoro; F. Biondi; E. Tenedini; E. Tagliafico; F. Vasuri; A. D’Errico; A. Dazzi; S. Pellegrini; G. Castellani; A. Procopio; M. Cescon; GL. Grazi; C. FranceschiM. Capri; F. Olivieri; D. Remondini; C. Lanzarini; R. Lazzarini; E. Bellavista; M. Martucci; A. Santoro; F. Biondi; E. Tenedini; E. Tagliafico; F. Vasuri; A. D’Errico; A. Dazzi; S. Pellegrini; G. Castellani; A. Procopio; M. Cescon; GL. Grazi; C. Francesch