Uptake, intracellular trafficking and pathologic effects of VacA toxin from Helicobacter pylori have been widely investigated in vitro. However, no systematic analysis investigated VacA intracellular distribution and fate in H. pylori-infected human gastric epithelium in vivo, using ultrastructural immunocytochemistry that combines precise toxin localization with analysis of the overall cell ultrastructure and intercompartimental/interorganellar relationships. By immunogold procedure, in this study we investigated gastric biopsies taken from dyspeptic patients to characterize the overall toxin's journey inside human gastric epithelial cells in vivo. Endocytic pits were found to take up VacA at sites of bacterial adhesion, leading to a popul...
Abstract VacA, the vacuolating cytotoxin A of Helicobacter pylori, induces apoptosis in epithelial c...
Helicobacter pylori produces a vacuolating cytotoxin, VacA, and most virulent H. pylori strains secr...
A key role in the carcinogenic action of Helicobacter pylori is played by the eector protein CagA, t...
Uptake, intracellular trafficking and pathologic effects of VacA toxin from Helicobacter pylori have...
Uptake, intracellular trafficking and pathologic effects of VacA toxin from Helicobacter pylori have...
Abstract The effect of vacuolating toxin (VacA) fromHelicobacter pylori on endosomal and lysosomal f...
Summary Helicobacter pylori is the causative agent of peptic ulcer disease. A major virulence factor...
Cells treated with the VacA toxin from Helicobacter pylori develop large membrane-bound vacuoles tha...
Intoxication of mammalian cells with the vacuolating toxin (VacA) released by Helicobacter pylori ca...
The vacuolating cytotoxin VacA is a major virulence factor of Helicobacter pylori, a bacterium respo...
VacA cytotoxin secreted by Helicobacter pylori causes cytoplasmic vacuolation in gastric epithelial ...
Helicobacter pylori secretes an approximately 88 kDa VacA toxin that is considered to be an importan...
Cells exposed to Helicobacter pylori toxin VacA develop large vacuoles that originate from massive s...
The attested association of Helicobacter pylori to gastro-duodenal pathologies such as chronic gastr...
The VacA toxin secreted by Helicobacter pylori enhances the ability of the bacteria to colonize the ...
Abstract VacA, the vacuolating cytotoxin A of Helicobacter pylori, induces apoptosis in epithelial c...
Helicobacter pylori produces a vacuolating cytotoxin, VacA, and most virulent H. pylori strains secr...
A key role in the carcinogenic action of Helicobacter pylori is played by the eector protein CagA, t...
Uptake, intracellular trafficking and pathologic effects of VacA toxin from Helicobacter pylori have...
Uptake, intracellular trafficking and pathologic effects of VacA toxin from Helicobacter pylori have...
Abstract The effect of vacuolating toxin (VacA) fromHelicobacter pylori on endosomal and lysosomal f...
Summary Helicobacter pylori is the causative agent of peptic ulcer disease. A major virulence factor...
Cells treated with the VacA toxin from Helicobacter pylori develop large membrane-bound vacuoles tha...
Intoxication of mammalian cells with the vacuolating toxin (VacA) released by Helicobacter pylori ca...
The vacuolating cytotoxin VacA is a major virulence factor of Helicobacter pylori, a bacterium respo...
VacA cytotoxin secreted by Helicobacter pylori causes cytoplasmic vacuolation in gastric epithelial ...
Helicobacter pylori secretes an approximately 88 kDa VacA toxin that is considered to be an importan...
Cells exposed to Helicobacter pylori toxin VacA develop large vacuoles that originate from massive s...
The attested association of Helicobacter pylori to gastro-duodenal pathologies such as chronic gastr...
The VacA toxin secreted by Helicobacter pylori enhances the ability of the bacteria to colonize the ...
Abstract VacA, the vacuolating cytotoxin A of Helicobacter pylori, induces apoptosis in epithelial c...
Helicobacter pylori produces a vacuolating cytotoxin, VacA, and most virulent H. pylori strains secr...
A key role in the carcinogenic action of Helicobacter pylori is played by the eector protein CagA, t...