Multi-target drug discovery (MTDD) is an emerging area of increasing interest to the drug discovery community. Drugs that modulate several targets have the potential for an improved balance of efficacy and safety compared to single targets agents. Although there are a number of marketed drugs that are thought to derive their therapeutic benefit by virtue of interacting with multiple targets, the majority of these were discovered accidentally. Written by world renowned experts, this is the first book to gather together knowledge and experiences of the rational discovery of multi-target drugs. It describes the current state of the art, the achievements and the challenges of the field and importantly the lessons learned by researchers to date ...
At present, the legendary magic bullet, i.e., a drug with high potency and selectivity toward a spec...
The diverse cerebral mechanisms implicated in Central Nervous System (CNS) diseases together with th...
HIGHLIGHTS Many CNS targets are being explored for multi-target drug designNew databases and cheminf...
Multi-target drug discovery (MTDD) is an emerging area of increasing interest to the drug discovery ...
The multifactorial nature of major neurodegenerative diseases and the current failures of the differ...
Diseases of infection, of neurodegeneration (such as Alzheimer's and Parkinson's diseases), and of m...
none7A review. The authors review the investigations reported in the past decade that illustrate th...
MULTI-TARGET-DIRECTED DRUGS FOR NEURODEGENERATION Carlo Melchiorre Alma Mater Studiorum – Universi...
The pharmaceutical industry is increasingly joining chemoinformatics in the search for the developme...
none3In recent years, the advent of the targeted therapy has significantly contributed to the increa...
The quest for new pharmacological treatments of neurodegenerative diseases (NDs) still remains a pri...
Preclinical Research A novel and promising approach to overcome the limits of single-target therapy ...
The diverse cerebral mechanisms implicated in CNS (Central Nervous System) diseases together with th...
No selective drugs exist, and we have been designing, synthesizing, and evaluating multitarget-direc...
At present, the legendary magic bullet, i.e., a drug with high potency and selectivity toward a spec...
The diverse cerebral mechanisms implicated in Central Nervous System (CNS) diseases together with th...
HIGHLIGHTS Many CNS targets are being explored for multi-target drug designNew databases and cheminf...
Multi-target drug discovery (MTDD) is an emerging area of increasing interest to the drug discovery ...
The multifactorial nature of major neurodegenerative diseases and the current failures of the differ...
Diseases of infection, of neurodegeneration (such as Alzheimer's and Parkinson's diseases), and of m...
none7A review. The authors review the investigations reported in the past decade that illustrate th...
MULTI-TARGET-DIRECTED DRUGS FOR NEURODEGENERATION Carlo Melchiorre Alma Mater Studiorum – Universi...
The pharmaceutical industry is increasingly joining chemoinformatics in the search for the developme...
none3In recent years, the advent of the targeted therapy has significantly contributed to the increa...
The quest for new pharmacological treatments of neurodegenerative diseases (NDs) still remains a pri...
Preclinical Research A novel and promising approach to overcome the limits of single-target therapy ...
The diverse cerebral mechanisms implicated in CNS (Central Nervous System) diseases together with th...
No selective drugs exist, and we have been designing, synthesizing, and evaluating multitarget-direc...
At present, the legendary magic bullet, i.e., a drug with high potency and selectivity toward a spec...
The diverse cerebral mechanisms implicated in Central Nervous System (CNS) diseases together with th...
HIGHLIGHTS Many CNS targets are being explored for multi-target drug designNew databases and cheminf...