Elastomeric electrospun scaffolds of poly(L-lactide-co-trimethylene carbonate) for myocardial tissue engineering

none7The development of synthetically bioengineered cardiac implants is believed to be an effective approach to restore impaired heart functions. One of the possibility is to develop a flexible patch sized to fit the infarcted area made out of a elastomeric biomaterial able to integrate with the surroundings and to promote cell functions. In this work a commercial random copolymer of (L)-lactic acid with trimethylene carbonate (P(L)LA-co-TMC) is used to fabricate a biomimetic electrospun scaffold and its potentialities for myocardial tissue engineering are investigated compared to poly(L)lactic acid (P(L)LA) electrospun scaffold.mixedM.L. Focarete; C. Gualandi; S. Mukherjee; R. Ravichandran; J. R. Venugopal; M. Raghunath; S. RamakrishnaM.L. Focarete; C. Gualandi; S. Mukherjee; R. Ravichandran; J. R. Venugopal; M. Raghunath; S. Ramakrishn