Nonsteroidal anti-inflammatory drugs possess antiproliferative activities that can affect cancer cells. The aim of this study was to examine the antiproliferative effects of ibuprofen on the MKN-45 cell line. Cells were treated with ibuprofen for 24, 48 or 72 h, and cell proliferation was evaluated by cell counting and [(3)H]-thymidine incorporation. Using microarray technology, we studied changes in the gene expression profiles over time after ibuprofen treatment. Ibuprofen induced a dose- and time-dependent reduction in cell number without altering cell viability. Genes involved in the 'biological oxidation' and 'G(1)/S checkpoint' pathways were the most significantly represented at 24 h, whereas genes involved in the 'cell cycle' and 'DN...
Non-steroidal anti-inflammatory drugs (NSAIDs) have been associated with anti-tumorigenic effects in...
The participation of mitochondria in the mechanism of tumor cell death induced by non-steroid anti-i...
Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) and is a widely used medication. One ind...
Nonsteroidal anti-inflammatory drugs possess antiproliferative activities that can affect cancer cel...
Ibuprofen is a non-steroidal anti-inflammatory drug of generalized use with over-the-counter availab...
BACKGROUND AND OBJECTIVE: Studies have shown that ibuprofen can have an anti-cancer effect on cervic...
Apoptosis plays a major role in gastrointestinal epithelial cell turnover, ulcerogenesis and tumorig...
Patrizia Bonelli,1 Franca M Tuccillo,1 Antonella Federico,5 Maria Napolitano,2 Antonella Borrelli,1 ...
Abstract: The serrated pathway to colorectal tumor formation involves oncogenic mutations in the BRA...
A major risk factor promoting tumor development is chronic inflammation and the use of nonsteroidal ...
<p><b>A</b>, Steady-state Tat2p-TAP levels are reduced upon ibuprofen treatment. Exponentially proli...
Aspirin- and non-steroidal anti-inflammatory drug (NSAID)-induced apoptosis is one of the important ...
Nonsteroidal anti-inflammatory drug (NSAID)-induced apoptosis is considered to be an important mecha...
Mesenchymal stromal cells (MSCs) are able to modulate the immune system activity and the regeneratio...
Non-steroidal anti-inflammatory drugs (NSAIDs) have been associated with anti-tumorigenic effects in...
Non-steroidal anti-inflammatory drugs (NSAIDs) have been associated with anti-tumorigenic effects in...
The participation of mitochondria in the mechanism of tumor cell death induced by non-steroid anti-i...
Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) and is a widely used medication. One ind...
Nonsteroidal anti-inflammatory drugs possess antiproliferative activities that can affect cancer cel...
Ibuprofen is a non-steroidal anti-inflammatory drug of generalized use with over-the-counter availab...
BACKGROUND AND OBJECTIVE: Studies have shown that ibuprofen can have an anti-cancer effect on cervic...
Apoptosis plays a major role in gastrointestinal epithelial cell turnover, ulcerogenesis and tumorig...
Patrizia Bonelli,1 Franca M Tuccillo,1 Antonella Federico,5 Maria Napolitano,2 Antonella Borrelli,1 ...
Abstract: The serrated pathway to colorectal tumor formation involves oncogenic mutations in the BRA...
A major risk factor promoting tumor development is chronic inflammation and the use of nonsteroidal ...
<p><b>A</b>, Steady-state Tat2p-TAP levels are reduced upon ibuprofen treatment. Exponentially proli...
Aspirin- and non-steroidal anti-inflammatory drug (NSAID)-induced apoptosis is one of the important ...
Nonsteroidal anti-inflammatory drug (NSAID)-induced apoptosis is considered to be an important mecha...
Mesenchymal stromal cells (MSCs) are able to modulate the immune system activity and the regeneratio...
Non-steroidal anti-inflammatory drugs (NSAIDs) have been associated with anti-tumorigenic effects in...
Non-steroidal anti-inflammatory drugs (NSAIDs) have been associated with anti-tumorigenic effects in...
The participation of mitochondria in the mechanism of tumor cell death induced by non-steroid anti-i...
Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) and is a widely used medication. One ind...