A decrease in extracellular calcium concentration ([Ca2+]o) leads to prolongation of action potential duration (APD) in ventricular cardiomyocytes and rate-corrected QT interval (QTc) in patients. Although this phenomenon is relevant to arrhythmogenesis in the clinical setting, its mechanisms are counterintuitive and incompletely understood. The aim of the present study was to identify the ionic mechanism/s likely to underlie the APD dependency on [Ca2+]o by using an in silico approach
Background: Spontaneous Ca2+ release from the sarcoplasmic reticulum (SCR) can cause delayed afterde...
AbstractThe L-type Ca2+ channel (CaV1.2) plays an important role in action potential (AP) generation...
In normal cardiac myocytes, the action potential duration (APD) is several hundred milliseconds. How...
A decrease in extracellular calcium concentration ([Ca2+]o) leads to prolongation of action potentia...
Reduction in [Ca2+]o prolongs the AP in ventricular cardiomyocytes and the QTc interval in patients....
The mechanisms underlying the inverse relation between extracellular calcium concentration ([Ca2+]o)...
A decrease in extracellular calcium concentration ([Ca2+]o) prolongs the action potential (AP) in ve...
Extracellular calcium concentration ([Ca2+]o) affects cardiac action potential (AP): their inverse d...
none3noRegulation of cardiac electrical and mechanical activities are highly dependent on L-type cal...
none5siThe importance of electrolyte concentrations for cardiac function is well established. Electr...
The importance of electrolyte concentrations for cardiac function is well established. Electrolyte v...
Abstract Background and aims Although studies on the relation between arrhythmias and the action pot...
ObjectivesThe purpose of this study was to determine whether abnormalities of calcium cycling explai...
Beat-to-beat variability of repolarization duration (BVR) is an intrinsic characteristic of cardiac ...
Background: Protracted QT interval (QTI) adaptation to abrupt heart rate (HR) changes has been ident...
Background: Spontaneous Ca2+ release from the sarcoplasmic reticulum (SCR) can cause delayed afterde...
AbstractThe L-type Ca2+ channel (CaV1.2) plays an important role in action potential (AP) generation...
In normal cardiac myocytes, the action potential duration (APD) is several hundred milliseconds. How...
A decrease in extracellular calcium concentration ([Ca2+]o) leads to prolongation of action potentia...
Reduction in [Ca2+]o prolongs the AP in ventricular cardiomyocytes and the QTc interval in patients....
The mechanisms underlying the inverse relation between extracellular calcium concentration ([Ca2+]o)...
A decrease in extracellular calcium concentration ([Ca2+]o) prolongs the action potential (AP) in ve...
Extracellular calcium concentration ([Ca2+]o) affects cardiac action potential (AP): their inverse d...
none3noRegulation of cardiac electrical and mechanical activities are highly dependent on L-type cal...
none5siThe importance of electrolyte concentrations for cardiac function is well established. Electr...
The importance of electrolyte concentrations for cardiac function is well established. Electrolyte v...
Abstract Background and aims Although studies on the relation between arrhythmias and the action pot...
ObjectivesThe purpose of this study was to determine whether abnormalities of calcium cycling explai...
Beat-to-beat variability of repolarization duration (BVR) is an intrinsic characteristic of cardiac ...
Background: Protracted QT interval (QTI) adaptation to abrupt heart rate (HR) changes has been ident...
Background: Spontaneous Ca2+ release from the sarcoplasmic reticulum (SCR) can cause delayed afterde...
AbstractThe L-type Ca2+ channel (CaV1.2) plays an important role in action potential (AP) generation...
In normal cardiac myocytes, the action potential duration (APD) is several hundred milliseconds. How...