The pathogenesis of Bronchiolitis Obliterans Syndrome (BOS), the main clinical phenotype of chronic lung allograft dysfunction, is poorly understood. Recent studies suggest that epigenetic regulation of microRNAs might play a role in its development. In this paper we present the application of a complex computational pipeline to perform enrichment analysis of miRNAs in pathways applied to the study of BOS. The analysis considered the full set of miRNAs annotated in miRBase (version 21), and applied a sequence of filtering approaches and statistical analyses to reduce this set and to score the candidate miRNAs according to their potential involvement in BOS development. Dysregulation of two of the selected candidate miRNAs-miR-34a and miR-21...
Chronic obstructive pulmonary disease (COPD) is characterized by a progressive airflow limitation an...
Bronchiolitis obliterans syndrome (BOS), the main manifestation of chronic lung allograft dysfunctio...
Chronic obstructive pulmonary disease (COPD) is characterized by a progressive airflow limitation an...
The pathogenesis of Bronchiolitis Obliterans Syndrome (BOS), the main clinical phenotype of chronic ...
The pathogenesis of Bronchiolitis Obliterans Syndrome (BOS), the main clinical phenotype of chronic ...
A complex computational pipeline to perform enrichment analysis of miRNAs in pathways was applied to...
Epigenetic changes, including miRNAs deregulation, have been suggested to play a significant role in...
Rationale: Pulmonary idiopathic fibrosis (IPF), Cryptogenetic organizing pneumonia (COP) and bronchi...
Lung transplantation (LTx) is the last treatment for patients suffering from end-stage lung diseases...
Inflammation; MicroRNA; Post‐infectious bronchiolitis obliteransInflamación; MicroARN; Bronquiolitis...
PhD ThesisDysregulation of miRNAs has been implicated in obstructive airway diseases including TGF-β...
Background: Specific diagnostic markers for congenital pulmonary airway malformations (CPAMs) have n...
Background: MicroRNAs (miRNAs) involved in the pathogenesis of pulmonary fibrosis have been shown to...
© 2017 The Author(s). Chronic obstructive pulmonary disease (COPD) is characterized by a progressive...
MicroRNAs (miRNAs) are small and non-coding RNA molecules that inhibit gene expression posttranscrip...
Chronic obstructive pulmonary disease (COPD) is characterized by a progressive airflow limitation an...
Bronchiolitis obliterans syndrome (BOS), the main manifestation of chronic lung allograft dysfunctio...
Chronic obstructive pulmonary disease (COPD) is characterized by a progressive airflow limitation an...
The pathogenesis of Bronchiolitis Obliterans Syndrome (BOS), the main clinical phenotype of chronic ...
The pathogenesis of Bronchiolitis Obliterans Syndrome (BOS), the main clinical phenotype of chronic ...
A complex computational pipeline to perform enrichment analysis of miRNAs in pathways was applied to...
Epigenetic changes, including miRNAs deregulation, have been suggested to play a significant role in...
Rationale: Pulmonary idiopathic fibrosis (IPF), Cryptogenetic organizing pneumonia (COP) and bronchi...
Lung transplantation (LTx) is the last treatment for patients suffering from end-stage lung diseases...
Inflammation; MicroRNA; Post‐infectious bronchiolitis obliteransInflamación; MicroARN; Bronquiolitis...
PhD ThesisDysregulation of miRNAs has been implicated in obstructive airway diseases including TGF-β...
Background: Specific diagnostic markers for congenital pulmonary airway malformations (CPAMs) have n...
Background: MicroRNAs (miRNAs) involved in the pathogenesis of pulmonary fibrosis have been shown to...
© 2017 The Author(s). Chronic obstructive pulmonary disease (COPD) is characterized by a progressive...
MicroRNAs (miRNAs) are small and non-coding RNA molecules that inhibit gene expression posttranscrip...
Chronic obstructive pulmonary disease (COPD) is characterized by a progressive airflow limitation an...
Bronchiolitis obliterans syndrome (BOS), the main manifestation of chronic lung allograft dysfunctio...
Chronic obstructive pulmonary disease (COPD) is characterized by a progressive airflow limitation an...