GH deficiency status combined with GH receptor polymorphism affects response to GH in children
- Valsesia, Armand
- Chatelain, Pierre
- Stevens, Adam
- Peterkova, Valentina A.
- Belgorosky, Alicia
- Maghnie, Mohamad
- Antoniazzi, Franco
- Koledova, Ekaterina
- Wojcik, Jerome
- Farmer, Pierre
- Destenaves, Benoit
- Clayton, Peter
- Ambler, G.
- Kapelari, K.
- Deal, C.
- Hamilton, J.
- Brusquet, Y.
- Chatelain, P.
- Colle, M.
- Coutant, R.
- Cabrol, S.
- Le Bouc, Y.
- Reynaud, R.
- Salles, J. P.
- Weill, J.
- Pfäffle, R.
- Ranke, M.
- Binder, G.
- Buzi, F.
- Pilotta, A.
- Cappa, M.
- Cicognani, A.
- Zucchini, S.
- Maghnie, M.
- Antoniazzi, F.
- Tatò, L.
- Kim, D. H.
- Yoo, H. W.
- Yang, S. W.
- Vangsøy Hansen, E.
- Veimo, D.
- Bashina, E.
- Skorodok, Y.
- Peterkova, V.
- Sultanova, L.
- Carrascosa, A.
- Yesta, D.
- Ferrandez Longas, A.
- Gracia Bouthellier, R.
- Gonzalez, I.
- Rodriguez Arnao, M. D.
- Rodriguez Sanchez, A.
- Lopez Siguero, J. P.
- Quinteiro, S.
- Dahlgren, J.
- Hagenäs, L.
- Wang, T. J.
- Hou, J. W.
- Bath, L.
- Kelnar, C.
- Clayton, P.
- BOZZOLA, MAURO
DOIAbstract
Meta-analysis has shown a modest improvement in first-year growth response to recombinant human GH (r-hGH) for carriers of the exon 3-deleted GH receptor (GHRd3) polymorphism but with significant interstudy variability. The associations between GHRd3 and growth response to r-hGH over 3 years in relation to severity of GH deficiency (GHD) were investigated in patients from 14 countries. Treatment-naïve pre-pubertal children with GHD were enrolled from the PREDICT studies (NCT00256126 and NCT00699855), categorized by peak GH level (peak GH) during provocation test: ≤4 μg/l (severe GHD; n>45) and >4 to <10 μg/l mild GHD; n=49) and genotyped for the GHRd3 polymorphism (full length (fl/fl, fl/d3, d3/d3). Gene expression (GE) profiles were charac...
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