Induced pluripotent stem cells (iPSC) offer a unique opportunity for developmental studies, disease modeling and regenerative medicine approaches in humans. The aim of our study was to create an in vitro 'patient-specific cell-based system' that could facilitate the screening of new therapeutic molecules for the treatment of catecholaminergic polymorphic ventricular tachycardia (CPVT), an inherited form of fatal arrhythmia. Here, we report the development of a cardiac model of CPVT through the generation of iPSC from a CPVT patient carrying a heterozygous mutation in the cardiac ryanodine receptor gene (RyR2) and their subsequent differentiation into cardiomyocytes (CMs). Whole-cell patch-clamp and intracellular electrical recordings of spo...
Human induced pluripotent stem cells (hiPSCs) offer significant opportunities for cardiac research. ...
Introduction Human induced pluripotent stem cells (hiPSCs) offer a unique opportunity for disease mo...
INTRODUCTION:Human induced pluripotent stem cells (hiPSCs) offer a unique opportunity for disease mo...
Induced pluripotent stem cells (iPSC) offer a unique opportunity for developmental studies, disease ...
Induced pluripotent stem cells (iPSC) offer a unique opportunity for developmental studies, disease ...
Induced pluripotent stem cells (iPSC) offer a unique opportunity for developmental studies, disease ...
Induced pluripotent stem cells (iPSC) offer a unique opportunity for developmental studies, disease ...
BACKGROUND: Induced pluripotent stem cells (iPSC) provide means to study the pathophysiology of gene...
Human induced pluripotent stem cells (hiPSCs) offer significant opportunities for cardiac research. ...
Background Induced pluripotent stem cells (iPSC) provide means to study the pathophysiology of ge...
Induced pluripotent stem cells (iPSC) provide means to study the pathophysiology of genetic disorder...
Induced pluripotent stem cells (iPSC) provide means to study the pathophysiology of genetic disorder...
BACKGROUND/AIMS: Induced pluripotent stem (iPS) cells generated from accessible adult cells of patie...
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an inherited arrhythmogenic disease ...
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an inherited arrhythmogenic disease ...
Human induced pluripotent stem cells (hiPSCs) offer significant opportunities for cardiac research. ...
Introduction Human induced pluripotent stem cells (hiPSCs) offer a unique opportunity for disease mo...
INTRODUCTION:Human induced pluripotent stem cells (hiPSCs) offer a unique opportunity for disease mo...
Induced pluripotent stem cells (iPSC) offer a unique opportunity for developmental studies, disease ...
Induced pluripotent stem cells (iPSC) offer a unique opportunity for developmental studies, disease ...
Induced pluripotent stem cells (iPSC) offer a unique opportunity for developmental studies, disease ...
Induced pluripotent stem cells (iPSC) offer a unique opportunity for developmental studies, disease ...
BACKGROUND: Induced pluripotent stem cells (iPSC) provide means to study the pathophysiology of gene...
Human induced pluripotent stem cells (hiPSCs) offer significant opportunities for cardiac research. ...
Background Induced pluripotent stem cells (iPSC) provide means to study the pathophysiology of ge...
Induced pluripotent stem cells (iPSC) provide means to study the pathophysiology of genetic disorder...
Induced pluripotent stem cells (iPSC) provide means to study the pathophysiology of genetic disorder...
BACKGROUND/AIMS: Induced pluripotent stem (iPS) cells generated from accessible adult cells of patie...
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an inherited arrhythmogenic disease ...
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an inherited arrhythmogenic disease ...
Human induced pluripotent stem cells (hiPSCs) offer significant opportunities for cardiac research. ...
Introduction Human induced pluripotent stem cells (hiPSCs) offer a unique opportunity for disease mo...
INTRODUCTION:Human induced pluripotent stem cells (hiPSCs) offer a unique opportunity for disease mo...