Survival and prognosis among 1545 patients with contemporary polycythemia vera: an international study.
- Tefferi A
- Finazzi G
- Gisslinger H
- Vannucchi AM
- Rodeghiero F
- Randi ML
- Vaidya R
- Rambaldi A
- Gisslinger B
- Pieri L
- Ruggeri M
- Bertozzi I
- Sulai NH
- Casetti I
- Carobbio A
- Jeryczynski G
- Larson DR
- Müllauer L
- Pardanani A
- Thiele J
- Passamonti F
- Barbui T.
- RUMI, ELISA
- CAZZOLA, MARIO
DOIAbstract
Under the auspices of an International Working Group, seven centers submitted diagnostic and follow-up information on 1545 patients with World Health Organization-defined polycythemia vera (PV). At diagnosis, median age was 61 years (51% females); thrombocytosis and venous thrombosis were more frequent in women and arterial thrombosis and abnormal karyotype in men. Considering patients from the center with the most mature follow-up information (n=337 with 44% of patients followed to death), median survival (14.1 years) was significantly worse than that of the age- and sex-matched US population (P<0.001). In multivariable analysis, survival for the entire study cohort (n=1545) was adversely affected by older age, leukocytosis, venous thrombo...
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