Serum Anti-Müllerian Hormone (AMH) and Inhibin (IB) levels in girls with isolated premature thelarche and with central precocious puberty

Background: Inhibin B (IB) and Anti-Müllerian hormone (AMH) are produced by the granulosa cells in small antral follicles and are sensitive markers of ovarian follicular activity. Unlike the IB, the AMH production has never been evaluated in girls with sexual precocity. Objective and hypotheses: The aim of this study was to determine the IB and AMH production in girls with premature thelarche (PT) and with central precocious puberty (CPP) and to investigate whether the production of these two hormones is influenced by the Gn-RHa therapy. Method: Heighty-seven girls were enrolled in this study: 25 girls with PT (1.2-7.8 yrs) and 62 girls with CPP of whom 30 girls (1.4-9.1 yrs) before Gn- RHa therapy and 32 (5.9-12.4 yrs) during Gn-RHa therapy. The control group consisted of 26 healthy prepubertal age-matched girls. Results: Inhibin B levels were higher in girls with PT and with CPP than in controls; the IB concentrations decreased during GN-RHa therapy. Unlike IB, AMH levels were significantly (p=0.011) lower in girls with PT than in girls with CPP, during GnRH-a treatment the AMH concentrations didn’t show variation respect to pretreatment values. The AMH levels were significantly (p