A review with 76 references. Second-generation antidepressant drugs are increasingly prescribed world-wide by psychiatrists and primary care physicians. Generally speaking, they seem to be safer than traditional tricyclic antidepressant drugs, especially in overdose. However, most of them possess stereogenic centres, thus they can exist as enantiomeric couples. Since enantiomers can have even dramatically different pharmacokinetic and pharmacodynamic properties, the study of antidepressant chirality is of great importance. In fact, the application of enantioselective analytical techniques can be useful both for the quality control of enantiomerically pure formulations and for the pharmacovigilance and therapeutic monitoring of patients unde...
Capillary electrophoresis has drawn considerable attention in the past few years, particularly in th...
A stereoselective HPLC assay has been developed to analyze the enantiomers of citalopram and of its ...
This research explores the application of a new technique, termed electrochemically modulated liquid...
A review with 76 references. Second-generation antidepressant drugs are increasingly prescribed worl...
Stereochemistry is steadily increasing in importance in the development of new drugs, and the availa...
Many antidepressants have been introduced as racemic drugs, the enantiomers of which may differ in s...
A stereospecific high-performance liquid chromatography (HPLC) method has been developed for the ana...
The aim of this work was finding suitable conditions for separation of enantiomers of citalopram and...
Mirtazapine is an antidepressant that acts specifically on noradrenergic and sertonergic receptors. ...
Mirtazapine (1,2,3,4,10,14b-hexahydro-2-methyl-pyrazino[2,1-a]-pyrido[2,3-c][2-benzazepine]), is the...
Mirtazapine is a recent noradrenergic and specific serotonergic antidepressant drug. A capillary ele...
Citalopram is a serotonin transporter (SERT) inhibitor and is used as a potent anti-depressant drug....
Capillary electrophoresis has drawn considerable attention in the past few years, particularly in th...
none2The introduction into clinical practice of the so-called second generation antidepressants has ...
The blood-brain barrier (BBB) is formed by the capillary endothelial cells, joined together by tight...
Capillary electrophoresis has drawn considerable attention in the past few years, particularly in th...
A stereoselective HPLC assay has been developed to analyze the enantiomers of citalopram and of its ...
This research explores the application of a new technique, termed electrochemically modulated liquid...
A review with 76 references. Second-generation antidepressant drugs are increasingly prescribed worl...
Stereochemistry is steadily increasing in importance in the development of new drugs, and the availa...
Many antidepressants have been introduced as racemic drugs, the enantiomers of which may differ in s...
A stereospecific high-performance liquid chromatography (HPLC) method has been developed for the ana...
The aim of this work was finding suitable conditions for separation of enantiomers of citalopram and...
Mirtazapine is an antidepressant that acts specifically on noradrenergic and sertonergic receptors. ...
Mirtazapine (1,2,3,4,10,14b-hexahydro-2-methyl-pyrazino[2,1-a]-pyrido[2,3-c][2-benzazepine]), is the...
Mirtazapine is a recent noradrenergic and specific serotonergic antidepressant drug. A capillary ele...
Citalopram is a serotonin transporter (SERT) inhibitor and is used as a potent anti-depressant drug....
Capillary electrophoresis has drawn considerable attention in the past few years, particularly in th...
none2The introduction into clinical practice of the so-called second generation antidepressants has ...
The blood-brain barrier (BBB) is formed by the capillary endothelial cells, joined together by tight...
Capillary electrophoresis has drawn considerable attention in the past few years, particularly in th...
A stereoselective HPLC assay has been developed to analyze the enantiomers of citalopram and of its ...
This research explores the application of a new technique, termed electrochemically modulated liquid...