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Synthesis of 1-Oxo-1-(3-pyridazinyl) Derivatives - Potent Inhibitors of Fatty Acid Amide Hydrolase (FAAH): An Improved and Optimized Procedure

  • ROSINI, GOFFREDO
  • MAROTTA, EMANUELA
  • TINARELLI, ALESSANDRO
  • RIGHI, PAOLO
  • D. G. Andreotti
  • P. D’Ambrosio
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Publication date
January 2007
Icon DOI
10.1055/s-2007-990774

Abstract

A greatly improved procedure for the preparation of long-chain α-ketopyridazines, a class of potent inhibitors of fatty acid amide hydrolase (FAAH), is described. This optimization study shows a great dependence of the yields of desired products on the pyrididazinyl lithium/Weinreb amide ratio and offers a general approach to this kind of compound

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