Effects of acetaldehyde produced by alcohol-containing mouthrinses on PDLFs

Antiseptic mouthrinses have valuable preventive roles in dental and oral diseases. There is also evidence that in caries prevention and in plaque control, they provide additive benefits. However most of them commercially available are source of alcohol. Recently the extraepatic alcohol metabolism has been demonstrated also in oral tissue. Interestingly, in the oral cavity, the activity of aldehyde-dehydrogenase (ALDH), enzyme that converts acetaldehyde into no-toxic acetate, is lower than activity of alcohol-dehydrogenase (ADH), responsible of the conversion of alcohol to acetaldehyde