Granulocyte/macrophage colony-stimulating factor (GM-CSF) autoantibodies (GMAb) are strongly associated with idiopathic pulmonary alveolar proteinosis (PAP) and are believed to be important in its pathogenesis. However, levels of GMAb do not correlate with disease severity and GMAb are also present at low levels in healthy individuals.Our primary objective was to determine whether human GMAb would reproduce PAP in healthy primates. A secondary objective was to determine the concentration of GMAb resulting in loss of GM-CSF signaling in vivo (i.e., critical threshold).Nonhuman primates (Macaca fascicularis) were injected with highly purified, PAP patient-derived GMAb in dose-ranging (2.2-50 mg) single and multiple administration studies, and...
Autoimmune pulmonary alveolar proteinosis (PAP) is a rare interstitial lung disease characterised by...
Autoimmune pulmonary alveolar proteinosis (aPAP) the most com-mon form of PAP (90%) is related to th...
Pulmonary alveolar proteinosis (PAP) is a rare syndrome characterized by the accumulation of surfact...
High levels of granulocyte/macrophage-colony-stimulating factor (GM-CSF) autoantibodies are thought ...
To the Editor: Idiopathic pulmonary alveolar proteinosis is a rare disease in which surfactant lipid...
Idiopathic pulmonary alveolar proteinosis is a rare disease in which surfactant lipids and proteins ...
Autoantibodies to multiple cytokines have been identified and some, including antibodies against gra...
The pathogenesis of acquired pulmonary alveolar proteinosis (PAP), a rare lung disease characterized...
Granulocyte macrophage colony stimulating factor (GM-CSF) is a key participant in, and a clinical ta...
AbstractMice deficient in granulocyte-macrophage colony stimulating factor (GM-CSF) develop pulmonar...
Pulmonary alveolar proteinosis (PAP) is a severe autoimmune disease caused by autoantibodies that n...
SummaryExistence of anti-granulocyte-macrophage colony-stimulating factor (GM-CSF) neutralizing anti...
We identified a 6-year-old girl with pulmonary alveolar proteinosis (PAP), impaired granulocyte-macr...
Pulmonary Alveolar Proteinosis (PAP) is a rare lung disease characterized by excessive accumulation ...
Pulmonary alveolar proteinosis is a rare clinical syndrome that was first described in 1958. Subsequ...
Autoimmune pulmonary alveolar proteinosis (PAP) is a rare interstitial lung disease characterised by...
Autoimmune pulmonary alveolar proteinosis (aPAP) the most com-mon form of PAP (90%) is related to th...
Pulmonary alveolar proteinosis (PAP) is a rare syndrome characterized by the accumulation of surfact...
High levels of granulocyte/macrophage-colony-stimulating factor (GM-CSF) autoantibodies are thought ...
To the Editor: Idiopathic pulmonary alveolar proteinosis is a rare disease in which surfactant lipid...
Idiopathic pulmonary alveolar proteinosis is a rare disease in which surfactant lipids and proteins ...
Autoantibodies to multiple cytokines have been identified and some, including antibodies against gra...
The pathogenesis of acquired pulmonary alveolar proteinosis (PAP), a rare lung disease characterized...
Granulocyte macrophage colony stimulating factor (GM-CSF) is a key participant in, and a clinical ta...
AbstractMice deficient in granulocyte-macrophage colony stimulating factor (GM-CSF) develop pulmonar...
Pulmonary alveolar proteinosis (PAP) is a severe autoimmune disease caused by autoantibodies that n...
SummaryExistence of anti-granulocyte-macrophage colony-stimulating factor (GM-CSF) neutralizing anti...
We identified a 6-year-old girl with pulmonary alveolar proteinosis (PAP), impaired granulocyte-macr...
Pulmonary Alveolar Proteinosis (PAP) is a rare lung disease characterized by excessive accumulation ...
Pulmonary alveolar proteinosis is a rare clinical syndrome that was first described in 1958. Subsequ...
Autoimmune pulmonary alveolar proteinosis (PAP) is a rare interstitial lung disease characterised by...
Autoimmune pulmonary alveolar proteinosis (aPAP) the most com-mon form of PAP (90%) is related to th...
Pulmonary alveolar proteinosis (PAP) is a rare syndrome characterized by the accumulation of surfact...