Add to ORKGThe processes of the present invention allow access to both enantiomeric series of non-natural alfa-amino acids. In a 1st aspect of the invention, there is a process for resolving racemic non-natural alfa-amino acids to provide an alfa-keto acid, achiral at the alfa-position, and a D-alfa-amino acid. In a 2nd aspect of the invention, there is a process for prepg. a non-natural L-alfa-amino acid from an alfa-keto acid, achiral at the alfa-position. Preferably, the achiral alfa-keto acid is provided from the process of the 1st aspect of the invention. All of the processes employ mutant amino acid dehydrogenases. The present invention shows that mutant amino acid dehydrogenases can, surprisingly, handle a wide range of non-natural alfa-am...
An efficient catalytic system is developed for racemization of amino acids. The system consists of a...
Abstract (R)- or (S)-2-Hydroxy-4-(methylthio)butanoic acid (HMTBA) is used as a poultry nutritional ...
l-Amino acid deaminase from Proteus myxofaciens (PmaLAAD) is a promising biocatalyst for enantiosele...
Enantiomerically pure α-amino acids are compounds of primary interest for the fine chemical, pharma...
Enantiomerically pure α-amino acids are compounds of primary interest for the fine chemical, pharma...
Many kinds of NAD(P)+-dependent L-amino acid dehydrogenases have been so far found and effectively u...
In nature, the D-enantiomers of amino acids (D-AAs) are not used for protein synthesis and during ev...
Unnatural amino acids, particularly synthetic a-amino acids, are becoming crucial tools for modern d...
Many kinds of NAD(P)+-dependent L-amino acid dehydrogenases have been so far found and effectively u...
The use of unnatural amino acids, particularly synthetic α-amino acids, for modern drug discovery re...
A general chemo-enzymatic process has been developed to prepare enantiomerically pure L- and D-amino...
Amino acid dehydrogenases (AADHs) are a group of enzymes that catalyze the reversible reductive amin...
One in four of the top 200 selling pharmaceutical drugs contain a chiral amine. Chiral amines often ...
Non-naturally occurring amine dehydrogenases (AmDH) and methods of use thereof the produce chiral am...
An efficient catalytic system is developed for racemization of amino acids. The system consists of a...
Abstract (R)- or (S)-2-Hydroxy-4-(methylthio)butanoic acid (HMTBA) is used as a poultry nutritional ...
l-Amino acid deaminase from Proteus myxofaciens (PmaLAAD) is a promising biocatalyst for enantiosele...
Enantiomerically pure α-amino acids are compounds of primary interest for the fine chemical, pharma...
Enantiomerically pure α-amino acids are compounds of primary interest for the fine chemical, pharma...
Many kinds of NAD(P)+-dependent L-amino acid dehydrogenases have been so far found and effectively u...
In nature, the D-enantiomers of amino acids (D-AAs) are not used for protein synthesis and during ev...
Unnatural amino acids, particularly synthetic a-amino acids, are becoming crucial tools for modern d...
Many kinds of NAD(P)+-dependent L-amino acid dehydrogenases have been so far found and effectively u...
The use of unnatural amino acids, particularly synthetic α-amino acids, for modern drug discovery re...
A general chemo-enzymatic process has been developed to prepare enantiomerically pure L- and D-amino...
Amino acid dehydrogenases (AADHs) are a group of enzymes that catalyze the reversible reductive amin...
One in four of the top 200 selling pharmaceutical drugs contain a chiral amine. Chiral amines often ...
Non-naturally occurring amine dehydrogenases (AmDH) and methods of use thereof the produce chiral am...
An efficient catalytic system is developed for racemization of amino acids. The system consists of a...
Abstract (R)- or (S)-2-Hydroxy-4-(methylthio)butanoic acid (HMTBA) is used as a poultry nutritional ...
l-Amino acid deaminase from Proteus myxofaciens (PmaLAAD) is a promising biocatalyst for enantiosele...