tert-Butyl Ethers: Renaissance of an Alcohol Protecting Group. Facile Cleavage with Cerium(III)Chloride/Sodium Iodide

none7Abstract: The tert-butoxy derivative is one of the most underused alcohol protectingg roups. After havingdeveloped an easy and useful protocol for its introduction, we offer here a simple procedure for its removal by treatment with anhydrous CeCl3 and NaI in CH3CN. The procedure led to the successful cleavage of aliphatic and aromatic tert-butyl ethers and was compatible with various other functionalities and protecting groups present in the molecule.mixedG. Bartoli; M. Bosco; A. Carlone; M. Locatelli; E. Marcantoni; P. Melchiorre; L. SambriG. Bartoli; M. Bosco; A. Carlone; M. Locatelli; E. Marcantoni; P. Melchiorre; L. Sambr