Add to ORKGWe have demonstrated induction of p53 and up-regulation of the p53 pathway in the human 5q– syndrome. This most probably results from haploinsufficiency of the ribosomal gene RPS14. The ribosome biogenesis checkpoint that results in activation of p53 protein and up-regulation of the p53 pathway offers a new potential therapeutic target in the human 5q– syndrome. However, this will be an option only if this intervention does not abrogate the critical tumor suppressor function of p5
Abstract Ribosome biogenesis and protein synthesis are fundamental rate-limiting steps for cell grow...
Ribosomopathies such as Diamond-Blackfan anemia (DBA) and 5q- syndrome are human diseases characteri...
Impairment of ribosome biogenesis leads to p53 induction and cell cycle arrest, a checkpoint involve...
In recent years we have gained great insight into the molecular pathogenesis of the 5q- syndrome, a ...
none11nonePellagatti A; Marafioti T; Paterson JC; Barlow JL; Drynan LF; Giagounidis A; Pileri SA; Ca...
In recent years we have gained great insight into the molecular pathogenesis of the 5q- syndrome, th...
The 5q- syndrome is the most distinct of the myelodysplastic syndromes (MDS) and patients with this ...
AbstractErrors in ribosome biogenesis can result in quantitative or qualitative defects in protein s...
SummarySeveral proto-oncogenes and tumor suppressors regulate the production of ribosomes. Ribosome ...
The identification of the genes associated with chromosomal translocation breakpoints has fundamenta...
We have previously demonstrated haploinsufficiency of the ribosomal gene RPS14, which is required fo...
Errors in ribosome biogenesis can result in quantitative or qualitative defects in protein synthesis...
We have previously demonstrated haploinsufficiency of the ribosomal gene RPS14, which is required fo...
Perturbations in ribosome biogenesis have been associated with cancer. Such aberrations activate p53...
The identification of the genes associated with chromosomal translocation breakpoints has fundamenta...
Abstract Ribosome biogenesis and protein synthesis are fundamental rate-limiting steps for cell grow...
Ribosomopathies such as Diamond-Blackfan anemia (DBA) and 5q- syndrome are human diseases characteri...
Impairment of ribosome biogenesis leads to p53 induction and cell cycle arrest, a checkpoint involve...
In recent years we have gained great insight into the molecular pathogenesis of the 5q- syndrome, a ...
none11nonePellagatti A; Marafioti T; Paterson JC; Barlow JL; Drynan LF; Giagounidis A; Pileri SA; Ca...
In recent years we have gained great insight into the molecular pathogenesis of the 5q- syndrome, th...
The 5q- syndrome is the most distinct of the myelodysplastic syndromes (MDS) and patients with this ...
AbstractErrors in ribosome biogenesis can result in quantitative or qualitative defects in protein s...
SummarySeveral proto-oncogenes and tumor suppressors regulate the production of ribosomes. Ribosome ...
The identification of the genes associated with chromosomal translocation breakpoints has fundamenta...
We have previously demonstrated haploinsufficiency of the ribosomal gene RPS14, which is required fo...
Errors in ribosome biogenesis can result in quantitative or qualitative defects in protein synthesis...
We have previously demonstrated haploinsufficiency of the ribosomal gene RPS14, which is required fo...
Perturbations in ribosome biogenesis have been associated with cancer. Such aberrations activate p53...
The identification of the genes associated with chromosomal translocation breakpoints has fundamenta...
Abstract Ribosome biogenesis and protein synthesis are fundamental rate-limiting steps for cell grow...
Ribosomopathies such as Diamond-Blackfan anemia (DBA) and 5q- syndrome are human diseases characteri...
Impairment of ribosome biogenesis leads to p53 induction and cell cycle arrest, a checkpoint involve...