Menstrual migraine, old and new

The authors reviewed the connection between sexual hormones and migraine crisis. Besides other exogenous factors, the fall of estradiol blood levels in the late luteal and premenstrual phase seems a causal factor in the origin of menstrual-related headache crisis. The behaviour of migraine crisis during the various events of female reproductive life, support this view. The role of PRL, T, FSH and LH was also discussed. On the other hand, menstrual migraine represents a model that fits perfectly with a neuroendocrine hypothesis which is based upon a faulty chronobiological response of the so-called antinociceptive system. PIP: The authors reviewed the connection between sex hormones and migraine crisis. Besides other exogenous factors, the fall in estradiol blood levels during the late luteal and premenstrual phase seems a causal factor in the origin of menstrual-related headaches. The behavior of migraine crisis during the various events of the female reproductive period support this view. The role of prolactin, follicle stimulating hormone, testosterone, and luteinizing hormone were also discussed. At the same time, menstrual migraine represents a model that fits perfectly with a neuroendocrine hypothesis which is based on a faulty chronobiological response of the so-called antinociceptive system. author's modified author's modifie