Platelet transfusion is currently the primary medical treatment for reducing thrombocytopenia in patients with inherited thrombocytopenias. To evaluate whether stimulating megakaryopoiesis could increase platelet count in these conditions, we treated patients with a severe thrombocytopenia induced by MYH9 mutations (MYH9-related disease) with a nonpeptide thrombopoietin receptor agonist, eltrombopag. Twelve adult patients with MYH9-RD and platelet counts of less than 50 × 10(9)/L received 50 mg of eltrombopag orally per day for 3 weeks. Patients who achieved a platelet count higher than 150 × 10(9)/L stopped therapy, those with 100 to 150 platelets × 10(9)/L continued treatment at the same eltrombopag dose for 3 additional weeks, while thos...
MYH9-related disease (MYH9-RD) is one of the most frequent forms of inherited thrombocytopenia. It i...
Hereditary thrombocytopenias (HTPs) constitute a heterogeneous group of diseases characterized by a ...
Platelets play a vital role in hemostasis. Until recently, there was nomeans to increase platelet pr...
Platelet transfusion is currently the primary medical treatment for reducing thrombocytopenia in pat...
Inherited thrombocytopenias (ITs) are a group of rare disorders characterized by reduced platelet co...
Patients with inherited thrombocytopenias often require platelet transfusions to raise platelet coun...
Patients with inherited thrombocytopenias often require platelet transfusions to raise their platele...
Patients with inherited thrombocytopenias often require platelet transfusions to raise platelet coun...
There is an unmet need for thrombopoietic agents that can increase platelet counts in patients with ...
Immune thrombocytopenia (ITP) is characterised by a transient or persistent decrease in platelets ac...
Thrombopoietin receptor agonists (TPO-RAs) are used as effective alternative treatments in ITP pati...
Eltrombopag is a small non-peptide thrombopoietin mimetic that has been approved for increasing plat...
Eltrombopag, a thrombopoietin mimetic peptide, may provide excellent clinical efficacy in steroid-r...
Background: Thrombocytopenia is a significant problem in patients with relapsed or refractory multip...
Background In myelodysplastic syndromes, thrombocytopenia is associated with mortality, but treatmen...
MYH9-related disease (MYH9-RD) is one of the most frequent forms of inherited thrombocytopenia. It i...
Hereditary thrombocytopenias (HTPs) constitute a heterogeneous group of diseases characterized by a ...
Platelets play a vital role in hemostasis. Until recently, there was nomeans to increase platelet pr...
Platelet transfusion is currently the primary medical treatment for reducing thrombocytopenia in pat...
Inherited thrombocytopenias (ITs) are a group of rare disorders characterized by reduced platelet co...
Patients with inherited thrombocytopenias often require platelet transfusions to raise platelet coun...
Patients with inherited thrombocytopenias often require platelet transfusions to raise their platele...
Patients with inherited thrombocytopenias often require platelet transfusions to raise platelet coun...
There is an unmet need for thrombopoietic agents that can increase platelet counts in patients with ...
Immune thrombocytopenia (ITP) is characterised by a transient or persistent decrease in platelets ac...
Thrombopoietin receptor agonists (TPO-RAs) are used as effective alternative treatments in ITP pati...
Eltrombopag is a small non-peptide thrombopoietin mimetic that has been approved for increasing plat...
Eltrombopag, a thrombopoietin mimetic peptide, may provide excellent clinical efficacy in steroid-r...
Background: Thrombocytopenia is a significant problem in patients with relapsed or refractory multip...
Background In myelodysplastic syndromes, thrombocytopenia is associated with mortality, but treatmen...
MYH9-related disease (MYH9-RD) is one of the most frequent forms of inherited thrombocytopenia. It i...
Hereditary thrombocytopenias (HTPs) constitute a heterogeneous group of diseases characterized by a ...
Platelets play a vital role in hemostasis. Until recently, there was nomeans to increase platelet pr...