Allogeneic hematopoietic stem cell transplantation in children and adolescents with recurrent and refractory Hodgkin lymphoma: an analysis of the European Group for Blood and Marrow Transplantation.
- CLAVIEZ A
- CANALS C
- DIERICKX D
- STEIN J
- BADELL I
- PESSION A
- MACKINNON S
- SLAVIN S
- DALLE JH
- CHACÓN MJ
- SARHAN M
- WYNN RF
- SUTTORP M
- DINI G
- SUREDA A
- SCHMITZ N
- DIERICKX D
- STEIN J
- BADELL I
- PESSION A
- MACKINNON S
- SLAVIN S
- DALLE JH
- JURADO CHACON M
- SARHAN M
- WYNN RF
- BUZYN A
- SUCAK G
- WILLEMZE R
- CARRERAS E
- BACIGALUPO A
- THOMSON K
- JOHNSON P
- FALDA M
- FOA R
- SCHATTENBERG A
- BACCARANI M
- BIRON P
- CORNELISSEN J
- WITZ F
- HAROUSSEAU JL
- LITTLEWOOD T
- SCHRAPPE A
- BROWN P
- JOUET P
- MESSINA C
- ROSSI G
- BRUNE M
- CAMPOS A
- MORRA E
- BOSI A
- PASTORE M
- KÖNIGSMANN M
- BAZARBACHI A
- CRADDOCK C
- NIEDERWIESER
- PETERS C
- SCHEID C
- LANGE A
- SAKELLARI I
- TOREN A
- LIBERATI M
- WANDT H
- UNAL A
- NEUBAUER A
- VITEK A
- BOURHIN JH
- BORDIGONI P
- KYRCZ KRZEMIEN S
- MASCHAN A
- AFANASYEV B
- DIAZ MA
- PORTA F
- GRAFAKOS S
- JACOBS P
- CASWELL M
- FAVRE C
- ARGIOLOU F
- KRIVAN G
- JIMINEZ S
- LUTZ P
- ROSSI J.F.
- LOCATELLI, FRANCO
DOIAbstract
Ninety-one children and adolescents 18 years or younger after allogeneic hematopoietic stem cell transplantation (HSCT) for relapsed or refractory Hodgkin lymphoma (HL) were analyzed. Fifty-one patients received reduced intensity conditioning (RIC); 40 patients received myeloablative conditioning (MAC). Nonrelapse mortality (NRM) at 1 year was 21% (+/- 4%), with comparable results after RIC or MAC. Probabilities of relapse at 2 and 5 years were 36% (+/- 5%) and 44% (+/- 6%), respectively. RIC was associated with an increased relapse risk compared with MAC; most apparent beginning 9 months after HSCT (P = .01). Progression-free survival (PFS) was 40% (+/- 6%) and 30% (+/- 6%) and overall survival (OS) was 54% (+/- 6%) and 45% (+/- 6%) at 2 a...
Add to ORKG