Determination of the targets of a compound remains an essential aspect in drug discovery. A complete understanding of all binding interactions is critical to recognize in advance both therapeutic effects and undesired consequences. However, the complete polypharmacology of many drugs currently in clinical development is still unknown, especially in the case of G protein-coupled receptor (GPCR) ligands. In this work we have developed a chemoproteomic platform based on the use of chemical probes to explore the target profile of a compound in biological systems. As proof of concept, this methodology has been applied to selected ligands of the therapeutically relevant serotonin 5-HT1A and 5-HT6 receptors, and we have identified and validated so...
Esta tesis doctoral presenta los resultados de la aplicación de varias técnicas computacionales al c...
Funder: Newton Fund RCUK-CONFAPFunder: Victorian Government’s Operational Infrastructure Support Pro...
While many disease-modifying protein targets have been discovered, most of these targets have remain...
Determination of the targets of a compound remains an essential aspect in drug discovery. A complet...
International audienceThe G-protein coupled receptor (GPCR) superfamily is currently the largest cla...
G protein-coupled receptors (GPCRs) represent the largest class of cell surface proteins and thus co...
G protein-coupled receptors (GPCRs), which are modulated by a variety of endogenous and synthetic li...
Although a plurality of drugs target G-protein-coupled receptors (GPCRs), most have emerged from cla...
GPCRs are one of the most important classes of proteins within the arena of drug discovery and thera...
The identification of subtype-selective GPCR (G-protein coupled receptor) ligands is a challenging t...
G-protein-coupled receptors (GPCRs) are frequent and fruitful targets for drug discovery and develop...
G‐protein‐coupled receptors (GPCRs) are the largest family of integral membrane receptors with key r...
The development of drugs that simultaneously target multiple receptors in a rational way (i.e., 'mag...
The primary goal of rational drug discovery is the identification of selective ligands which act on ...
G protein-coupled receptors (GPCRs) are essential mediators of cellular signaling and important targ...
Esta tesis doctoral presenta los resultados de la aplicación de varias técnicas computacionales al c...
Funder: Newton Fund RCUK-CONFAPFunder: Victorian Government’s Operational Infrastructure Support Pro...
While many disease-modifying protein targets have been discovered, most of these targets have remain...
Determination of the targets of a compound remains an essential aspect in drug discovery. A complet...
International audienceThe G-protein coupled receptor (GPCR) superfamily is currently the largest cla...
G protein-coupled receptors (GPCRs) represent the largest class of cell surface proteins and thus co...
G protein-coupled receptors (GPCRs), which are modulated by a variety of endogenous and synthetic li...
Although a plurality of drugs target G-protein-coupled receptors (GPCRs), most have emerged from cla...
GPCRs are one of the most important classes of proteins within the arena of drug discovery and thera...
The identification of subtype-selective GPCR (G-protein coupled receptor) ligands is a challenging t...
G-protein-coupled receptors (GPCRs) are frequent and fruitful targets for drug discovery and develop...
G‐protein‐coupled receptors (GPCRs) are the largest family of integral membrane receptors with key r...
The development of drugs that simultaneously target multiple receptors in a rational way (i.e., 'mag...
The primary goal of rational drug discovery is the identification of selective ligands which act on ...
G protein-coupled receptors (GPCRs) are essential mediators of cellular signaling and important targ...
Esta tesis doctoral presenta los resultados de la aplicación de varias técnicas computacionales al c...
Funder: Newton Fund RCUK-CONFAPFunder: Victorian Government’s Operational Infrastructure Support Pro...
While many disease-modifying protein targets have been discovered, most of these targets have remain...