Activation-induced deaminase (AID) initiates antibody diversification in germinal center (GC) B cells through the deamination of cytosines on immunoglobulin genes. AID can also target other regions in the genome, triggering mutations or chromosome translocations, with major implications for oncogenic transformation. However, understanding the specificity of AID has proved extremely challenging. We have sequenced at very high depth > 1,500 genomic regions from GC B cells and identified 275 genes targeted by AID, including 30 of the previously known 35 AID targets. We have also identified the most highly mutated hotspot for AID activity described to date. Furthermore, integrative analysis of the molecular features of mutated genes coupled to ...
D ow nloaded from The generation of an efficient immune response depends on highly refined mechanism...
Activation-induced deaminase (AID) initiates secondary antibody diversification in germinal center B...
D ow nloaded from The generation of an efficient immune response depends on highly refined mechanism...
Activation-induced deaminase (AID) initiates antibody diversification in germinal center (GC) B cell...
Activation-induced deaminase (AID) initiates antibody diversification in germinal center (GC) B cell...
Activation-induced deaminase (AID) initiates antibody diversification in germinal center (GC) B cell...
B lymphocytes are key effectors of the humoral immune response through the secretion of antibodies. ...
The processes of secondary antibody diversification are initiated by the mutagenic, B cell specific ...
The processes of secondary antibody diversification are initiated by the mutagenic, B cell specific ...
Editing Ig genes by activation induced deaminase (AID) initiates the antibody diversification proces...
Genomic complexity in non-Hodgkin’s Diffuse Large B-cell Lymphoma (DLBCL) leads to a treatment failu...
Activation-induced deaminase (AID) is required for somatic hypermutation in immunoglobulin genes, bu...
International audienceActivation-induced deaminase (AID), a member of the AID/apolipoprotein B mRNA-...
International audienceActivation-induced deaminase (AID), a member of the AID/apolipoprotein B mRNA-...
International audienceActivation-induced deaminase (AID), a member of the AID/apolipoprotein B mRNA-...
D ow nloaded from The generation of an efficient immune response depends on highly refined mechanism...
Activation-induced deaminase (AID) initiates secondary antibody diversification in germinal center B...
D ow nloaded from The generation of an efficient immune response depends on highly refined mechanism...
Activation-induced deaminase (AID) initiates antibody diversification in germinal center (GC) B cell...
Activation-induced deaminase (AID) initiates antibody diversification in germinal center (GC) B cell...
Activation-induced deaminase (AID) initiates antibody diversification in germinal center (GC) B cell...
B lymphocytes are key effectors of the humoral immune response through the secretion of antibodies. ...
The processes of secondary antibody diversification are initiated by the mutagenic, B cell specific ...
The processes of secondary antibody diversification are initiated by the mutagenic, B cell specific ...
Editing Ig genes by activation induced deaminase (AID) initiates the antibody diversification proces...
Genomic complexity in non-Hodgkin’s Diffuse Large B-cell Lymphoma (DLBCL) leads to a treatment failu...
Activation-induced deaminase (AID) is required for somatic hypermutation in immunoglobulin genes, bu...
International audienceActivation-induced deaminase (AID), a member of the AID/apolipoprotein B mRNA-...
International audienceActivation-induced deaminase (AID), a member of the AID/apolipoprotein B mRNA-...
International audienceActivation-induced deaminase (AID), a member of the AID/apolipoprotein B mRNA-...
D ow nloaded from The generation of an efficient immune response depends on highly refined mechanism...
Activation-induced deaminase (AID) initiates secondary antibody diversification in germinal center B...
D ow nloaded from The generation of an efficient immune response depends on highly refined mechanism...