Differentiation of naive CD4(+) T-cells into functionally distinct T helper (Th) subsets is critical to immunity against pathogen infection. Little is known about the role of signals emanating from the nuclear envelope for T-cell differentiation. The nuclear envelope protein lamin A/C is induced in naive CD4(+) T-cells upon antigen recognition and acts as a link between the nucleus and the plasma membrane during T-cell activation. Here we demonstrate that the absence of lamin A/C in naive T-cell reduces Th1 differentiation without affecting Th2 differentiation in vitro and in vivo. Moreover, Rag1(-/-) mice reconstituted with Lmna(-/-)CD4(+)CD25(-) T-cells and infected with vaccinia virus show weaker Th1 responses and viral removal than mice...
AbstractNaive T helper cells differentiate into two subsets, Th1 and Th2, each with distinct functio...
The protective immune response to intracellular parasites involves in most cases the differentiation...
Mutations and defects in nuclear lamins can cause major pathologies, including inflammation and infl...
In many cell types, nuclear A-type lamins regulate multiple cellular functions, including higher-ord...
The mechanisms by which lamin A/C in CD4+ T-cells control intestinal homeostasis and can cause infla...
Nuclear envelope lamin A/C proteins are a major component of the mammalian nuclear lamina, a dense ...
Nuclear lamins A/C control several critical cellular functions, e.g., chromatin organization, gene t...
Nuclear envelope lamin A/C proteins are a major component of the mammalian nuclear lamina, a dense f...
Experimental leishmaniasis offers a well characterized model of T helper type 1 cell (Th1)-mediated ...
The mammalian immune system has evolved distinct strategies for combatting a wide variety of pathoge...
SummaryT-bet is a critical transcription factor for T helper 1 (Th1) cell differentiation. To study ...
The recruitment of dendritic cells to sites of infections and their migration to lymph nodes is fund...
In contrast to the development of Th1 (type 1 T helper cells), Th17 and Treg (regulatory T cells), l...
An attractive strategy to improve efficacy of current Influenza A Virus (IAV) vaccines is to promote...
In this issue of Immunity, Lin et al. (2009) implicate interleukin-17 in the regulation of T helper ...
AbstractNaive T helper cells differentiate into two subsets, Th1 and Th2, each with distinct functio...
The protective immune response to intracellular parasites involves in most cases the differentiation...
Mutations and defects in nuclear lamins can cause major pathologies, including inflammation and infl...
In many cell types, nuclear A-type lamins regulate multiple cellular functions, including higher-ord...
The mechanisms by which lamin A/C in CD4+ T-cells control intestinal homeostasis and can cause infla...
Nuclear envelope lamin A/C proteins are a major component of the mammalian nuclear lamina, a dense ...
Nuclear lamins A/C control several critical cellular functions, e.g., chromatin organization, gene t...
Nuclear envelope lamin A/C proteins are a major component of the mammalian nuclear lamina, a dense f...
Experimental leishmaniasis offers a well characterized model of T helper type 1 cell (Th1)-mediated ...
The mammalian immune system has evolved distinct strategies for combatting a wide variety of pathoge...
SummaryT-bet is a critical transcription factor for T helper 1 (Th1) cell differentiation. To study ...
The recruitment of dendritic cells to sites of infections and their migration to lymph nodes is fund...
In contrast to the development of Th1 (type 1 T helper cells), Th17 and Treg (regulatory T cells), l...
An attractive strategy to improve efficacy of current Influenza A Virus (IAV) vaccines is to promote...
In this issue of Immunity, Lin et al. (2009) implicate interleukin-17 in the regulation of T helper ...
AbstractNaive T helper cells differentiate into two subsets, Th1 and Th2, each with distinct functio...
The protective immune response to intracellular parasites involves in most cases the differentiation...
Mutations and defects in nuclear lamins can cause major pathologies, including inflammation and infl...