Previously, we described that acetylsalicylic acid (ASA) decreases HCV expression, but the mechanisms involved have not been clearly established. We evaluated the participation of inducible nitric oxide synthase (iNOS) in the regulation of HCV-RNA induced by ASA. Huh7 cells expressing non-structural HCV proteins were exposed to 4 mM ASA and incubated at the same times we reported HCV downregulation (24-72 h), and iNOS mRNA and protein levels were then measured by real-time PCR and Western blot, respectively. Nitric oxide levels were measured at the same time. Inhibition of iNOS mRNA by small interfering RNAs (siRNA) and activation of the iNOS gene promoter by ASA treatment were evaluated. In Huh7 replicon cells treated with ASA, we found de...
In this thesis, chemical biology approaches were used to study Hepatitis C Virus (HCV) in non-infect...
<p>(A) Reduction of intracellular HCV RNA levels in cells that over-express ABCA1. Huh7.5 cells were...
Background: Hepatitis C virus (HCV) infection is a global health problem. A number of studies have i...
Previously, we described that acetylsalicylic acid (ASA) decreases HCV expression, but the mechanism...
We evaluated the participation of oxidative stress in the negative regulation of hepatitis C virus (...
It has been reported that salicylates (sodium salicylate and aspirin) inhibit the replication of fla...
Background and aim. Acetylsalicylic acid (ASA) has been shown to downregulate HCV expression; howeve...
SummaryBackgroundChronic liver disorders represent a serious health problem. Nitric oxide (NO) synth...
PubMedID: 17553719Background: Chronic liver disorders represent a serious health problem. Nitric oxi...
RIG-I and MDA5 are the major intracellular sensors for the induction of IFN-β, by dsRNA, in Huh7 cel...
Hepatitis C virus (HCV) is a small positive-sense single-stranded RNA virus that causes severe liver...
Host cell factors are critical to all stages of the hepatitis C virus (HCV) life cycle. While many c...
[[abstract]]©2004 ASM - Hepatitis C virus (HCV) is a serious global problem, and present therapeutic...
ABSTRACT Nitric oxide is a versatile and critical effector molecule that can modulate many cellular ...
AbstractHepatitis C virus (HCV) RNA replication requires cellular factors as well as viral non-struc...
In this thesis, chemical biology approaches were used to study Hepatitis C Virus (HCV) in non-infect...
<p>(A) Reduction of intracellular HCV RNA levels in cells that over-express ABCA1. Huh7.5 cells were...
Background: Hepatitis C virus (HCV) infection is a global health problem. A number of studies have i...
Previously, we described that acetylsalicylic acid (ASA) decreases HCV expression, but the mechanism...
We evaluated the participation of oxidative stress in the negative regulation of hepatitis C virus (...
It has been reported that salicylates (sodium salicylate and aspirin) inhibit the replication of fla...
Background and aim. Acetylsalicylic acid (ASA) has been shown to downregulate HCV expression; howeve...
SummaryBackgroundChronic liver disorders represent a serious health problem. Nitric oxide (NO) synth...
PubMedID: 17553719Background: Chronic liver disorders represent a serious health problem. Nitric oxi...
RIG-I and MDA5 are the major intracellular sensors for the induction of IFN-β, by dsRNA, in Huh7 cel...
Hepatitis C virus (HCV) is a small positive-sense single-stranded RNA virus that causes severe liver...
Host cell factors are critical to all stages of the hepatitis C virus (HCV) life cycle. While many c...
[[abstract]]©2004 ASM - Hepatitis C virus (HCV) is a serious global problem, and present therapeutic...
ABSTRACT Nitric oxide is a versatile and critical effector molecule that can modulate many cellular ...
AbstractHepatitis C virus (HCV) RNA replication requires cellular factors as well as viral non-struc...
In this thesis, chemical biology approaches were used to study Hepatitis C Virus (HCV) in non-infect...
<p>(A) Reduction of intracellular HCV RNA levels in cells that over-express ABCA1. Huh7.5 cells were...
Background: Hepatitis C virus (HCV) infection is a global health problem. A number of studies have i...