Add to ORKGThe MLL-AF9 oncogene originates from the translocation t(9;11)(p22;q23), which is mainly associated with monocytic acute myeloid leukaemia (AML-M5; FAB-classification). In AML-M5 THP-1 cells carrying t(9;11) (p22;q23) and expressing MLL-AF9, we previously showed that MLL-AF9 expression is down-regulated during monocyte-macrophage maturation. We have subsequently observed that in a 'rapid-growing' variant of the THP-1 cell line (THP-1-R) MLL-AF9 down-regulation does not occur. MLL fusion proteins (including MLL-AF9) deregulate MYC transactivation activity, and both presence and absence of MYC down-regulation have been reported during monocyte-macrophage maturation in THP-1 cells. In the present study, we analyze the expression patterns of ML...
Leukemias that harbor translocations involving the mixed lineage leukemia gene (MLL) possess unique ...
Chromosomal translocation t(9;11)(p22;q23) in acute myeloid leukemia fuses the MLL and AF9 genes. We...
MLL amplification was recently recognized as a recurrent aberration in acute myeloid leukemia (AML) ...
The MLL-AF9 oncogene originates from the translocation t(9;11)(p22;q23), which is mainly associated ...
The MLL-AF9 oncogene - one of the most frequent MLL/HRX/ALL-1 rearrangements found in infantile and ...
The translocation t(9;11)(p22;q23) generates the MLL-AF9 oncogene and is commonly associated with mo...
Abstract. The translocation t(9;11)(p22;q23) generates the MLL-AF9 oncogene and is commonly associat...
SummaryThe pathways by which oncogenes, such as MLL-AF9, initiate transformation and leukemia in hum...
Rearrangements of the MLL (ALL1) gene are very common in acute infant and therapy-associated leukemi...
Rearrangements of the MLL (ALL1) gene are very common in acute infant and therapy-associated leukemi...
cated on human chromosome 11q23, are frequent in both infant and therapy-related leukemias. Gene exp...
AML is associated with several genetic and epi-genetic events that result in malignant transfor-mati...
Patients with a t(9;11) translocation (MLL-AF9) develop acute myeloid leukemia (AML), and while in m...
The AF9 protein is one of the most common chromosomal translocation partners of the MLL gene in MLL ...
Background: Translocations of the Mixed Lineage Leukemia (MLL) gene occur in a subset (5%) of acute ...
Leukemias that harbor translocations involving the mixed lineage leukemia gene (MLL) possess unique ...
Chromosomal translocation t(9;11)(p22;q23) in acute myeloid leukemia fuses the MLL and AF9 genes. We...
MLL amplification was recently recognized as a recurrent aberration in acute myeloid leukemia (AML) ...
The MLL-AF9 oncogene originates from the translocation t(9;11)(p22;q23), which is mainly associated ...
The MLL-AF9 oncogene - one of the most frequent MLL/HRX/ALL-1 rearrangements found in infantile and ...
The translocation t(9;11)(p22;q23) generates the MLL-AF9 oncogene and is commonly associated with mo...
Abstract. The translocation t(9;11)(p22;q23) generates the MLL-AF9 oncogene and is commonly associat...
SummaryThe pathways by which oncogenes, such as MLL-AF9, initiate transformation and leukemia in hum...
Rearrangements of the MLL (ALL1) gene are very common in acute infant and therapy-associated leukemi...
Rearrangements of the MLL (ALL1) gene are very common in acute infant and therapy-associated leukemi...
cated on human chromosome 11q23, are frequent in both infant and therapy-related leukemias. Gene exp...
AML is associated with several genetic and epi-genetic events that result in malignant transfor-mati...
Patients with a t(9;11) translocation (MLL-AF9) develop acute myeloid leukemia (AML), and while in m...
The AF9 protein is one of the most common chromosomal translocation partners of the MLL gene in MLL ...
Background: Translocations of the Mixed Lineage Leukemia (MLL) gene occur in a subset (5%) of acute ...
Leukemias that harbor translocations involving the mixed lineage leukemia gene (MLL) possess unique ...
Chromosomal translocation t(9;11)(p22;q23) in acute myeloid leukemia fuses the MLL and AF9 genes. We...
MLL amplification was recently recognized as a recurrent aberration in acute myeloid leukemia (AML) ...