The poor prognosis associated with medulloblastoma (MB) has stimulated the evaluation of improved treatment strategies. The potential of lovastatin, an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, as a possible anticancer drug against MB was evaluated in vitro. Analysis of cell morphologic changes, cell viability, DNA fragmentation and flow cytometry demonstrated growth inhibition and induction of apoptosis in MB cells and lovastatin 'resistant' MB cells after lovastatin treatment. Cell cycle arrest in G1 was concomitant with apoptosis. Mevalonate prevented lovastatin-induced changes in MB, thus confirming that blockage of the mevalonate pathway is a critical step in the mechanism of lovastatin-induce...
<div><p>Background</p><p>Medulloblastoma (MB) is the most common pediatric primary malignant brain t...
© 2014 Othman et al.; licensee BioMed Central Ltd. Introduction: Medulloblastoma (MB) is the most co...
The statin family of hydroxymethylglutaryl coenzyme A reductase (HMGCR) inhibitors, used to control ...
The poor prognosis associated with medulloblastoma (MB) has stimulated the evaluation of improved t...
Medulloblastoma is a common pediatric brain tumor and one of the main types of solid cancers in chil...
Mevalonic aciduria (MA), the most severe form of mevalonate kinase deficiency (MKD), is still an orp...
Mevalonic aciduria (MA), the most severe form of mevalonate kinase deficiency (MKD), is still an orp...
AbstractWe recently identified 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, the rate-l...
We recently demonstrated that 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, the rate-li...
grantor: University of TorontoApoptosis, programmed cell death, is triggered by abrogation...
HMG-CoA reductase inhibitors induce apoptosis in mouse proximal tubular cells in primary culture. Re...
Medulloblastoma is the most common malignant brain tumor of childhood. Novel therapeutic strategies ...
Abstract: Lovastatin, an HMG-CoA reductase inhibitor, was found to suppress growth and induce apopto...
Medulloblastoma (MB) is the most common pediatric primary malignant brain tumor. Approximately one-t...
Lovastatin, a competitive inhibitor of the mevalonate pathway, is commonly prescribed for the treatm...
<div><p>Background</p><p>Medulloblastoma (MB) is the most common pediatric primary malignant brain t...
© 2014 Othman et al.; licensee BioMed Central Ltd. Introduction: Medulloblastoma (MB) is the most co...
The statin family of hydroxymethylglutaryl coenzyme A reductase (HMGCR) inhibitors, used to control ...
The poor prognosis associated with medulloblastoma (MB) has stimulated the evaluation of improved t...
Medulloblastoma is a common pediatric brain tumor and one of the main types of solid cancers in chil...
Mevalonic aciduria (MA), the most severe form of mevalonate kinase deficiency (MKD), is still an orp...
Mevalonic aciduria (MA), the most severe form of mevalonate kinase deficiency (MKD), is still an orp...
AbstractWe recently identified 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, the rate-l...
We recently demonstrated that 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, the rate-li...
grantor: University of TorontoApoptosis, programmed cell death, is triggered by abrogation...
HMG-CoA reductase inhibitors induce apoptosis in mouse proximal tubular cells in primary culture. Re...
Medulloblastoma is the most common malignant brain tumor of childhood. Novel therapeutic strategies ...
Abstract: Lovastatin, an HMG-CoA reductase inhibitor, was found to suppress growth and induce apopto...
Medulloblastoma (MB) is the most common pediatric primary malignant brain tumor. Approximately one-t...
Lovastatin, a competitive inhibitor of the mevalonate pathway, is commonly prescribed for the treatm...
<div><p>Background</p><p>Medulloblastoma (MB) is the most common pediatric primary malignant brain t...
© 2014 Othman et al.; licensee BioMed Central Ltd. Introduction: Medulloblastoma (MB) is the most co...
The statin family of hydroxymethylglutaryl coenzyme A reductase (HMGCR) inhibitors, used to control ...