Chemotherapy is the predominant approach for treating cancer. However, disease relapse frequently occurs because chemotherapy often fails to eliminate all tumor cells due to intrinsic or acquired drug resistance. The failure of conventional chemotherapeutics regimes for cancer highlights the need for novel therapeutic interventions. Recent studies have shown that human Rad51, an evolutionarily conserved DNA recombinase required for homologous recombination, exhibits elevated expression in many cancer cells and is implicated in drug resistance after chemotherapy. Targeted inhibition of human Rad51 has been explored as a way to sensitize cancer cells to chemotherapy. Given the properties of antibodies and their fragments as high-affinity...
The cellular proteome, in both healthy and diseased cells, is presented on the cell membrane surface...
Thesis (Ph.D.)--University of Rochester. School of Medicine & Dentistry. Dept. of Biochemistry and B...
RAD51 is a key protein in the homologous recombination (HR) pathway of DNA double-strand break repai...
Chemotherapy is the predominant approach for treating cancer. However, disease relapse frequently o...
<div><p>The homologous recombination pathway is responsible for the repair of DNA double strand brea...
The homologous recombination pathway is responsible for the repair of DNA double strand breaks. RAD5...
Genome integrity is constantly affected by DNA damage and replication errors due to exogenous and en...
A key challenge in the development of novel chemotherapeutics is the design of molecules capable of ...
My PhD research project has been finalized to the discovery of potential RAD51-BRCA2 protein-protein...
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, 2005.Vita.Inc...
Over the last two decades, a major focus in the biomedical research community has been placed on und...
Germline BRCA mutations underlay a significant risk for breast and ovarian cancer that increases in ...
The developments of antibodies for cancer therapeutics have made remarkable success in recent years....
PURPOSE: Fibroblast activation protein (FAP) is a serine protease that has emerged as a promising ta...
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, February 2010...
The cellular proteome, in both healthy and diseased cells, is presented on the cell membrane surface...
Thesis (Ph.D.)--University of Rochester. School of Medicine & Dentistry. Dept. of Biochemistry and B...
RAD51 is a key protein in the homologous recombination (HR) pathway of DNA double-strand break repai...
Chemotherapy is the predominant approach for treating cancer. However, disease relapse frequently o...
<div><p>The homologous recombination pathway is responsible for the repair of DNA double strand brea...
The homologous recombination pathway is responsible for the repair of DNA double strand breaks. RAD5...
Genome integrity is constantly affected by DNA damage and replication errors due to exogenous and en...
A key challenge in the development of novel chemotherapeutics is the design of molecules capable of ...
My PhD research project has been finalized to the discovery of potential RAD51-BRCA2 protein-protein...
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, 2005.Vita.Inc...
Over the last two decades, a major focus in the biomedical research community has been placed on und...
Germline BRCA mutations underlay a significant risk for breast and ovarian cancer that increases in ...
The developments of antibodies for cancer therapeutics have made remarkable success in recent years....
PURPOSE: Fibroblast activation protein (FAP) is a serine protease that has emerged as a promising ta...
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, February 2010...
The cellular proteome, in both healthy and diseased cells, is presented on the cell membrane surface...
Thesis (Ph.D.)--University of Rochester. School of Medicine & Dentistry. Dept. of Biochemistry and B...
RAD51 is a key protein in the homologous recombination (HR) pathway of DNA double-strand break repai...