Add to ORKGMost multi-alignment methods are fully automated, i.e. they are based on a fixed set of mathematical rules. For various reasons, such methods may fail to produce biologically meaningful alignments. Herein, we describe a semi-automatic approach to multiple sequence alignment where biological expert knowledge can be used to influence the alignment procedure. The user can specify parts of the sequences that are biologically related to each other; our software program uses these sites as anchor points and creates a multiple alignment respecting these user-defined constraints. By using known functionally, structurally or evolutionarily related positions of the input sequences as anchor points, our method can produce alignments that reflect the t...
Sammeth M, Morgenstern B, Stoye J. Divide-and-conquer multiple alignment with segment-based constrai...
The level of conservation between two homologous sequences often varies among sequence regions; func...
Recent advances in evolutionary modelling and alignment methodology mean that today accurate and fas...
Most multi-alignment methods are fully automated, i.e. they are based on a fixed set of mathematical...
Abstract: In many situations, automated multi-alignment programs are not able to correctly align fam...
Background: Automated software tools for multiple alignment often fail to produce biologically meani...
Sequence alignment has become one of the most common tasks in bioinformatics. Most of the existing s...
An essential tool in biology is the alignment of multiple sequences. Biologists use multiple sequenc...
Alignment of multiple DNA or protein sequences is a cen-tral problem in computational biology. To cr...
Motivation: Many multiple sequence alignment tools have been developed in the past, progressing eith...
With the rapid development of genome sequencing, an ever-increasing number of molecular biology anal...
Multiple sequence alignment plays a key role in the computational analysis of biological data. Diffe...
Multiple sequence alignment is an alignment of three or more protein or nucleic acid sequences. The...
The alignment of biological sequences is crucial for the transfer of annotation from model organisms...
Background: Aligning multiple sequences arises in many tasks in Bioinformatics. However, the alignm...
Sammeth M, Morgenstern B, Stoye J. Divide-and-conquer multiple alignment with segment-based constrai...
The level of conservation between two homologous sequences often varies among sequence regions; func...
Recent advances in evolutionary modelling and alignment methodology mean that today accurate and fas...
Most multi-alignment methods are fully automated, i.e. they are based on a fixed set of mathematical...
Abstract: In many situations, automated multi-alignment programs are not able to correctly align fam...
Background: Automated software tools for multiple alignment often fail to produce biologically meani...
Sequence alignment has become one of the most common tasks in bioinformatics. Most of the existing s...
An essential tool in biology is the alignment of multiple sequences. Biologists use multiple sequenc...
Alignment of multiple DNA or protein sequences is a cen-tral problem in computational biology. To cr...
Motivation: Many multiple sequence alignment tools have been developed in the past, progressing eith...
With the rapid development of genome sequencing, an ever-increasing number of molecular biology anal...
Multiple sequence alignment plays a key role in the computational analysis of biological data. Diffe...
Multiple sequence alignment is an alignment of three or more protein or nucleic acid sequences. The...
The alignment of biological sequences is crucial for the transfer of annotation from model organisms...
Background: Aligning multiple sequences arises in many tasks in Bioinformatics. However, the alignm...
Sammeth M, Morgenstern B, Stoye J. Divide-and-conquer multiple alignment with segment-based constrai...
The level of conservation between two homologous sequences often varies among sequence regions; func...
Recent advances in evolutionary modelling and alignment methodology mean that today accurate and fas...