Gadolinium-loaded polychelating amphiphilic polymer as an enhanced MRI contrast agent for human multiple myeloma and non Hodgkin's lymphoma (human Burkitt's lymphoma)
- D. Kozlowska
- S. Biswas
- E. K. Fox
- B. Wu
- F. Bolster
- O. Prakash Edupuganti
- V. Torchilin
- S. Eustace
- R. O'Kennedy
- D. F. Brougham
- BOTTA, Mauro
Publication date
January 2014
DOI Publisher
Royal Society of Chemistry (RSC) ISSN
2046-2069 Citation count (estimate)
6Abstract
Liposomes, loaded with gadolinium (Gd) ions using different membrane-incorporated chelating lipids and functionalized with monoclonal anti-CD138 (syndecan-1) antibody were prepared. Nuclear Magnetic Resonance Dispersion (NMRD) analysis showed that use of the polychelating amphiphilic polymer (PAP) increases both the Gd content and the spin–lattice relaxivity of the Gd-loaded-PAP–liposomes as compared to Gd–DTPA–BSA equivalents. The potential application of contrast syndecan-1– and Rituximab–liposomes, for application as a novel minimally invasive diagnostic agent for multiple myeloma and non Hodgkin's lymphoma was investigated
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