Telomere loss in Philadelphia-negative hematopoiesis after successful treatment of chronic myeloid leukemia: Evidence for premature aging of the myeloid compartment
- Lobetti Bodoni C
- Ferrero D
- Genuardi E
- Passera R
- Bernocco E
- Sia D
- Grignani G
- Crisà E
- Monitillo L
- Rocci A
- Drandi D
- Giai V
- Zanni M
- Boi M
- Isaia G
- Barbero D
- Lunghi M
- Abruzzese E
- Radaelli F
- Pini M
- Pregno P
- Carlo Stella C
- Boccadoro M
- Ladetto M.
- GAIDANO, Gianluca
DOIAbstract
Telomere shortening, a well-known marker of aging and cellular stress, occurs under several conditions in the hematopoietic compartment, including aplastic anemia and following iatrogenic noxae. We decided to verify whether pathological telomere erosion also arises in restored Philadelphia-negative (Ph-negative) hematopoiesis following successful treatment of chronic myeloid leukemia (CML). Eighty-one CML patients in complete cytogenetic remission were compared to 76 age-matched healthy subjects. Myeloid cells of CML patients had shorter telomeres than controls (6521 bp vs 7233 bp, p<0.001). This difference was specific for the myeloid compartment, since it was not observed in lymphoid cells (6774 bp vs 6909 bp, p=0.620). Acquired Ph-negati...
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