In this paper EEG and Holter EEG data compression techniques which allow perfect reconstruction of the recorded waveform from the compressed one are presented and discussed. Data compression makes it possible to achieve significant reduction in the space required to store signals and in transmission time. The Huffman coding technique in conjunction with derivative computation reaches high compression ratios (on average 49% on Holter and 58% on EG signals) with low computational complexity. By exploiting this result a simple and fast encoder/decoder scheme capable of real time performance on a PC was implemented. This simple technique is compared with other predictive transformations, vector quantization, discrete cosine transform and repeti...