Muscular modifications in chronic spinal cord injured patients

In this thesis muscular modifications in chronic spinal cord injured patients have been investigated. Using a translational approach, a mini-invasive muscular biopsy technique in Spinal Cord Injured patients has been validated. Moreover, the possible role of circulating levels of myostatin as a possible candidate biomarker for muscular modifications in chronic SCI patients has been evaluated. Lastly, the molecular modifications of PGE2 pathway on muscular specimens of chronic SCI patients has been studied. All material is original and based on direct Author \u2019s experience