Effectiveness of laboratory analysis for predicting osteoporotic vertebral fractures in men

Cilj istraživanja: Cilj je rada ispitati povezanost standardnih laboratorijskih vrijednosti krvi i urina i novonastalih osteoporotskih lomova trupa kralješka u muškaraca. Uspješnost će se definirati postojanjem povezanosti između značajnih promjena laboratorijskih vrijednosti i pojavnosti lomova trupa kralješka u populaciji ispitanih muškaraca. Nacrt studije: Istraživanje je provedeno kao presječna studija na 36 ispitanika muškog spola u dobi između 50 i 84 godine. Ispitanici i metode: Podaci o pacijentima muškog spola prikupljeni su pomoću BIS-a u Zavodu za ortopediju i traumatologiju KBC-a Osijek. Radi se o 36 pacijenata muškog spola koji su unazad posljednjih šest mjeseci doživjeli lom trupa kralješka, a da su pritom prije ili neposredno nakon učinjene vertebroplastike učinili standardne laboratorijske testove krvi i urina. Analizirane su standardne vrijednosti krvi i urina i njihova povezanost s brojem, lokalizacijom i rizikom nastanka novih osteoporotskih prijeloma trupa kralježaka. Rezultati: S obzirom na lokalizaciju, osam (22%) ispitanika ima prijelom lumbalnog, 17 (47%) ispitanika torakalnog dijela, dok ih 11 (31%) ispitanika ima prijelom i torakalnog i lumbalnog dijela kralježnice, značajno je veći broj prijeloma bio kod ispitanika koji imaju prijelome i lumbalnog i torakalnog dijela kralježnice. Uočene su značajno niže vrijednosti hemoglobina kod ispitanika s prijelomom u lumbalnom dijelu kralježnice, dok u ostalim biokemijskim vrijednostima nema značajnih razlika, također postoji značajna povezanost fosfata u urinu i broja prijeloma. Kod ispitanika koji imaju prijelom lumbalnog i torakalnog dijela kralježnice, značajna je povezanost broja prijeloma s ALT-om. Zaključak: Obradom dobivenih podataka utvrđeno je da ne postoji značajna povezanost između standardnih laboratorijskih vrijednosti krvi i urina i rizika za nastanak prijeloma trupa kralješka.The objective: The objective of this paper work is to study the connection between reference values of blood and urine tests and newly formed osteoporotic fractures of vertebral body. The success of the research will be defined by establishing the connection between significant change in blood test values and the occurrence of vertebral fractures among the population of men participating in the research. The outline of the study: The research was conducted as an average study on 36 male subjects ranging from 50 to 84 years old. Subjects and methods: The information about the male patients was collected from the Central Information System of Department of orthopaedics and trauma at the University Hospital Centre in Osijek. The study included 36 male patients who have suffered spinal fracture in the last six months and who have done standardized laboratory blood and urine tests before or immediately after the vertebroplasty. The study analysed reference blood and urine values and their association with the number and position of the fracture as well as the risk of new osteoporotic vertebral fractures. Results: Considering the location of the fracture, 8 (22%) research subjects suffered a fracture of thoracic, 17 (47 %) of lumbar and 11 (31 % )of both thoracic and lumbar spine. There was a larger number of fractures among the patients with lumbar and thoracic spinal fractures. The study showed lower values of haemoglobin with research subjects with lumbar fractures whereas there was no significant change in other biochemical analysis results. Furthermore, there was a visible connection between the level of phosphates in the urine and the number of fractures. Among the research subjects who had both thoracic and lumbar fracture, there was a connection between the number of fractures and ALT values. Conclusion: After analysis and processing of research data, it is concluded that there is no significant connection between the reference values of blood and urine laboratory tests and the risk of vertebral fracture