A critical point for manufacturing companies has always been the optimization of their production processes to increase the productivity and minimize the related costs, chasing an efficiency principle. Thanks to advent of Industry 4.0 (I4.0) era, some technologies, perceived as far away few years ago, now can be reached by everyone. The use of these technologies allows factories to acquire and evaluate their production data (and much more) and carry out complex analyses in short time making possible the improvement of the production processes. Aim of this paper is to propose a methodological framework in which, starting from an existing process, where workers and machines have already been assigned to each station of a production line, the ...