POTENSI EKSTRAK BAWANG PUTIH (Allium Sativum) SEBAGAI ANTI ALERGI PADA MENCIT YANG DIINDUKSI DENGAN OVALBUMIN

The potency of garlic extract as antiallergy in rat were investigated. Garlic extract was evaluated for antiallergy effect by ovalbumin-induced rat paw edema. Sprague Dawley Rats were divided into the control groups were saline perorally, garlic exctract groups received doses of 100; 200 and 400 mg/kg garlic extract (peroral) respectively. This was followed by the administration ovalbumin at dose 500 ug/kg BW through the intraplantar route 30 min after administration piperine or saline. After the ovalbumin injection was measurement of paw volume. The garlic exctract in doses of 100; 200 and 400 mg/kg BW showed 5,4%; 43,8% and 54,8% inhibition of paw edema respectively at the end of three hours. The increase in paw volume after ovalbumin injection was significantly prevented by preadministration of the garlic exctract at 400 mg/kg BW but not garlic extract at 100 and 200 mg/kg BW. These results suggest that garlic exctract at dose 400 mg/kg BW has antiallergy properties