DAYA ANTHELMINTIKA EKSTRAK ETANOL DAUN SIRIH MERAH (Piper crocatum) TERHADAP CACING Fasciola gigantica SECARA IN VITRO

The aims of this study is to know the anthelmintic activity of ethanol extract of red betel leaf (Piper crocatum) against Fasciola gigantica worm in vitro, as well as knowing lethal dose 50 and lethal time 50. Method that used in the research was completely randomized design. There were five treatments and each treatment was done in four replications. This research used ten Fasciola gigantica in each treatment for all replications. The observation and recording of dead Fasciola gigantica was done at 2, 4, 6, 8 and 10 hours. Fasciola gigantica were declared dead if there was no movement when disturbed by anatomy tweezers and when dipped in slightly warm water (50℃). The obtained data was analyzed using ANAVA and continued with Duncan Multiple Range Test. The result of this research show that ethanol of extract of red betel leaf (Piper crocatum) has anthelmintic effects against Fasciola gigantica worm in vitro. In the extract with 25% concentration, there is anthelmintics property that almost the same as Nitroxynil. The higher the concentration of the extract, the higher the property of anthelmintic. In probit analysis show tha