DRUG UTILIZATION STUDY IN HOSPITALIZED PATIENTS WITH PULMONARY TUBERCULOSIS IN SAIFUL ANWAR TEACHING HOSPITAL

BACKGROUND Tuberculosis (TB) is one of the main health problems because of its morbidity and mortality, especially in develoving countryies such as Indonesia Household Health Survey at 1995, TB was in the third rank of mortality causes. An appropriate treatment of TB infection and disease is very lengthy, and must be monitored for adverse drug effects and effectiveness of treatment. Current guidelines for TB infection are daily isoniazid (INH) for six months adults, and 12 months in children and immunosuppressed individuals OBJECTIVE The study was designed to analyze the drug utilization in patients with pulmonary tuberculosis who were caring in Saiful Anwar Teaching Hospital, Malang METHOD The prospective observational method was conducted in this study with descriptive analysis. The 45 of hospitalized TB patiens was collected at pulmonary ward of Saiful Anwar Teaching Hospital, Malang, during 3 months period of April 1st until June 31st 2007 RESULTS The ratio distribution of hospitalized TB patients in Saiful Anwar Teaching Hospital, Malang is 40% male and 60% female. All of patients suffered from clinical symptoms related to the TB such as slight cough with mucoid sputum, weakness, night sweats, loss of appetite and weight. Our data demonstrated that 88% patients with pulmonary TB received anti TB drugs. Beside of anti-TB drugs, patients also received broadspectrum antibiotic (fluoroquinolon and cephalosporin) for secondary infection, antitussive for cough, analgesic for chest pain, antipyretic for fever, H2 blocker for peptic ulcer and vitamin B for the avoiding adverse drug reaction. The using of TB drugs based on the classification of it diseases status. The 31.8% patients with chronic state recived combination of rifampicin, isoniazid, pyrazinamide and ethambutol (RHZE) (31.8% patients). The several cases (11.6% patients) were given combination of rifampicin and isoniazid (RH). Futbennore, the new TB cases were treated by rifampicin, isoniazid, pyrazinamid and ethambutol (RHZE) (50.00/o patients); rifampicin, isoniazid, pyrazinamide and ethambutol (RHZE adjuvant) (2.7% patients). After treatment with combination of TB drugs, the majority patient getting recored condition (44.73%) and improving condition and 5.3% were died. During the course of therapy, the advers drug reactions also appeared in several cases. Conclusion: freatment TB that 1t consists of multiple druqs and lonq-term administration has effective to recover the pulmonary tuberculosis with several adverse drug reactions