PROFILE OF ANTIEPILEPTIC DRUGS EFFECT IN PATIENT’S SLEEP CYCLE

Background. Epilepsy and sleep well recognized has bidirectional influences upon one another. The effects of antiepileptic drugs (AEDs) on sleep are of particular concern. Aim. The objective of this study is to know the profile of AEDs effect in patient’s sleep cycle. Methods. This descriptive observational study observes total sleep time, sleep onset latency, sleep efficiency, daytime drowsiness, insomnia, and parasomnia in epileptic patient with AEDs of Neurology Clinic Airlangga University Hospital during May- September 2016. A cross sectional study is done by quetionnaire and interview directly to the epileptic patients. Data collected is being analyzed descriptively and the significance tested by ANOVA one-way test. Results. Sleep disturbances that been found in patients with phenytoin are prolong sleep onset latency (11.11%), decrease sleep efficiency (11.11%), and daytime drowsiness (66.67%). Sleep disturbances that been found in patients with valproate are decrease total sleep time (33.33%), prolong sleep onset latency (11.11%), decrease sleep efficiency (11.11%), daytime drowsiness (66.67%), and insomnia (11.11%). Sleep disturbances that been found in patients with carbamazepine are decrease total sleep time (44.44%), prolong sleep onset latency (33.33%), decrease sleep efficiency (22.22%), daytime drowsiness (77.78%), and insomnia (11.11%). Conclusion. In conclusion, this study shows that epileptic patients who consumed AEDs regularly may have sleep disturbance that vary based on the type of AEDs. Epileptic patients with carbamazepine may have bigger sleep disturbance than patients with phenytoin and valproate. It is necessary to give information and education to the epileptic patients who consumed AEDs regularly so that they will become aware of the sign of sleep disturbance