PENGARUH PEMBENTUKAN KOKRISTAL QUERCETIN - ASAM SUKSINAT YANG DIBUAT DENGAN METODE SOLVENT DROP GRINDING (SDG) TERHADAP KARAKTERISTIK FISIKOKIMIANYA

Quercetin is a flavonoid that has an activity as a strong antioxidant agents. Nevertheless, quercetin has bioavailability problem due to its poor solubility in water. In order to improve solubility of quercetin, cocrystals method was applied. Cocrystals of quercetin were succesfully produced with succinic acid as conformer at molar ratio 1:1 prepared by Solvent Drop Grinding (SDG) method with the addition of different organic solvents. Their physicochemical characteristics was investigated using Differential Scanning Calorymetri (DSC), X-Ray Diffraction (XRD), Scanning Electron Microscopy (SEM), and Fourier Transform Infrared Spectrophotometer (FTIR). The results from DSC and XRD showed that cocrystal obtained with organic solvent addition formed new crystallin phase. The microphotographs from SEM showed that KKet and KKmet formed different crystal habit than cocrystal components. The FTIR demonstrated that quercetin formed intermolecular hydrogen bonding with succinic acid in both cocrystals formed