PENGARUH PEMBERIAN KOLOSTRUM SUSU SAPI TERHADAP PENURUNAN TINGKAT KERUSAKAN HEPAR DAN DAYA HIDUP PADA MENCIT (Mus musculus) YANG DI INFEKSI Toxoplasma gondii

The aim of this research is to determine the lifespan and histopathological changes of mice liver which infected by tachyzoites of Toxoplasma gondii intraperitoneal. Experimental animal used 36 male mice 2-3 month were divided randomly into two group treatment (n=9). K(+) as a control given aquadest steril 0.3ml orally, grup was infected with 1x103 of Toxoplasma gondii tachyzoites. P1 as a treatment bovine colostrum 0.3ml orally, grup was infected with 1x103 of Toxoplasma gondii tachyzoites. Four days post infection, mice were sacificed and liver of all mice taken for histopathology preparations for further observation. Each of the liver of mice (Mus musculus) processed by Hematoxylin eosin staining. The results of the observation and scoring degeneration and necrosis of the entire liver histopathology preparation of mice (Mus musculus) were analyzed statistically using the Mann-Whitney test. Based on the result of the Mann-Whitney test showed that there were significantly different result of degeneration and necrosis. Otherwise the result of t-test showed that there were insignificantly different result of degeneration and necrosis. Thus the result showed that bovine colostrum was succesfully improved the lifespan and histopathological alterations of mice