UJI TOKSISITAS PRA KLINIS FORMULA VAKSIN ROTAVIRUS TERHADAP GAMBARAN HISTOPATOLOGI ORGAN USUS HALUS KELINCI JANTAN

This research aimed to prove the influence of administered orally rotavirus vaccine formula from P.T Biofarma on histopathological changes of small intestine in male rabbits (Oryctolagus cuniculus). Six male rabbits were divided randomly into two groups and administered orally based on the treatment. The treatment consists of administered sucrose 1 ml orally (P0) and the administered of rotavirus vaccine formula P.T Biofarma 1 ml orally (P1). Rabbits adapted in BSL-3 for 7 days with adlibitum food and water before treatment. 1 ml sucrose and 1 ml rotavirus vaccine formula from P.T Biofarma was administered orally on day-0, day-11 and day-22. Then, on day 56 all rabbits euthanized for small instestine sample collection. The histopathological feature of small intestine were examined by using Modified Ciarlet et al., (1998) scoring methode. This research was analyzed using Mann-Whitney Test, then Mann-Whitney Test of statistical analyses showed that rotavirus vaccine formula has no effect on histopathological features of male rabbit’s small intestine organ (p > 0.05)