KARAKTERISASI KOMPLEKS INKLUSI ASAM P- METOKSISINAMAT (APMS)-β-SIKLODEKSTRIN (Dibuat dengan Metode Evaporasi)

p-Methoxycinnamic Acid (pMCA) is a compound obtained from the hydrolysis of ethyl-p-methoxycinnamate (EPMC) which has an anti inflammation activity. pMCA has very low solubility in water. To increase its solubility an inclusion complex of pMCA and β-cyclodextrin were made with molar ratio 1:1. Inclusion complex prepared with evaporation method by dissolving pMCA and β-cyclodextrin in 200 ml of 12% aqueous ethanol then evaporated using Rotary Evaporator at 70˚C with rotation speed 400 rpm. The inclusion complex formed was analyzed with DTA,FTIR, and Powder X-Ray Diffraction (PXRD), compared with pMCA, β-cyclodextrin, and physical mixture of p-MCA-β-cyclodextrin. Analysis using DTA showed a broadened peak and decrease of intensity for inclusion complex compared with physical mixture and single compound substance. FTIR study of inclusion complex formed showed that C-H aromatic and C=O carboxylic spectra which are specific for pMCA has a different absorption band compared with the physical mixture. Analysis using PXRD showed decrease of intensity between inclusion complex formed compared with pMCA. UV spectra profile of inclusion complex formed showed no difference with pMCA spectra profile therefore the pMCA content in inclusion complex formed can be determined. Recovery of pMCA content in inclusion complex was 92,45 %, this study showed the uniformity of pMCA content in inclusion complex formed. Dissolution profile of inclusion complex gave a better dissolution rate compared with p-MCA and physical mixture. The statistical analysis with one way anova showed significance < 0,05, therefore a difference dissolution rate between inclusion complex, p-MCA, and physical mixture. The results of the characterization and dissolution profile method showed that inclusion compex of pMCA and β-cyclodextrin can be formed using evaporation method. Keywords : p-Methoxycinnamic Acid, β-cyclodextrin, inclusion complex, evaporation, characterization, dissoluti