KARAKTERISASI KOMPLEKS INKLUSI ASAM para METOKSI SINAMAT (APMS) – β-SIKLODEKSTRIN (Dibuat dengan Metode Microwave Irradiation)

Abstract : para methoxy cinnamic acid (pMCA) is a major substance synthetized from Kaempferia galanga Linn. It has an analgesic effect but poor solubility in water, therefore it was formed as inclusion complex to enhance its solubility. The aims of this study was to investigate characterization and the dissolution rate of inclusion complex between (pMCA) and (-CD) prepared by microwave irradiation method. The inclusion complex was reacted in 1:1 stoichiometry and used chloroform as a solvent using microwave for four minutes and 80 % of power (400 watt). The inclusion complex was characterizated by some analitycal method such as X-Ray Diffractometer (XRD), Fourier Transform Infrared Spectroscopy (FTIR), and Differential Thermal Analysis (DTA). The formed inclusion complex was proven having different physical properties compared to it single substance and it physical mixture with a higher yield of product (96,47 %) and shorter time of reaction than the conventional method. Inclusion complex dissolution rate profile showed a higher slope and ED60 parameters compared to physical mixture and pMCA, from these parameters above it proved that inclusion complex was formed and the dissolution rate of pMCA was increased. Keyword : Inclusion complex, para-methoxy cinnamic acid, -cyclodextrin, characterization, dissolution rate, microwave irradiation method