SINTESIS SENYAWA ASAM 5-METOKSI-2-(4-METILBENZOILOKSI) BENZOAT DAN UJI AKTIVITAS ANALGESIKNYA PADA MENCIT (Mus musculus)

Synthesis of 5-methoxy-2-(4-methylbenzoyloxy)benzoate Acid And It Anlgesic Activity Test In Mice (Mus musculus) Putri Kusniawati The perpuse of the research is to synthesis novel of derivate salycilic acid 5-metoxy-2-(4-methylbenzoyloxy)benzoate acid and it analgesic activity test in mice. 5-metoxy-2-(4-methylbenzoyloxy)benzoate acid synthesized with modification Schotten Baumann method by reacting 5-methoxy salycilic acid and 4-methylbenzoil chloride. Pyridine as catalyst and THF as solvent. The result obtained 33.65% from synthesis. After that purity test with 2 method are thin layer chromathography and melting point test. The structure confirmed by UV spectrophotometry, infrared spectrophotometry and 1H-NMR spectrometry method. It analgesic activity tested with writhing test method. And the result are ED50 of 5-methoxy-2- (4-methylbenzoyloxy)benzoate acid is 22,78 mg/kg body weight and ED50 of acetosal is 80,26 mg/kg body weight. It concluded that 5-methoxy-2-(4- methylbenzoyloxy)benzoate acid have higher analgesic activity than acetosal. Keyword: synthesis, 5-metoxy-2-(4-methylbenzoyloxy)benzoate acid, analgesic activity, ED5