Two novel, modified thymidine nucleosides, 5-phenylselenyl-methyl-2'-deoxyuridine (PhSe-T) and 5-methylselenyl-methyl-2'-deoxyuridine (MeSe-T), trigger reactive oxygen species (ROS) generation and DNA damage and thereby induce caspase-mediated apoptosis in human HL-60 cells; however, the mechanism leading to caspase activation and apoptotic cell death remains unclear. Therefore, we investigated the signaling molecules involved in nucleoside derivative-induced caspase activation and apoptosis in HL-60 cells. PhSe-T/MeSe-T treatment activated two mitogen-activated protein kinases (MAPKs), extracellular-receptor kinase (ERK) and p38, and induced the phosphorylation of two downstream targets of p38, ATF-2 and MAPKAPK2. In addition, the selectiv...
Cisplatin is one of the major chemotherapeutic weapons used against different human cancers, althoug...
ABSTRACT The by-product of lipid peroxidation, 4-hydroxynonenal (HNE), was shown to cause apoptosis ...
The stress-activated c-Jun N-terminal protein kinase (JNK) and p38 mitogen-activated protein (MAP) k...
In the present study, we investigated the signaling pathways implicated in the induction of apoptosi...
The aim of the present study was to discover the signaling pathways associated with 2-(3...
TNF-α transduces signals of survival or death via its two receptors, R1/p55/p60 and RII/p80/p75. The...
The role of p38 mitogen-activated protein kinase (MAPK) in apoptosis is a matter of debate. Here, we...
Toll-like receptor (TLR) 2 functions as a sensor for detecting various microbial components conserve...
AbstractA selective p38 MAP kinase (p38 MAPK) inhibitor, SB202190, induced apoptotic cell death of a...
Activation of the mitotic checkpoint by chemotherapeutic drugs such as taxol causes mammalian cells ...
In the present study we examined in more detail the dual role of the c-JUN N-terminal kinase (JNK) a...
Sphingosine induces activation of multiple signaling pathways that play critical roles in controllin...
The present study aims to determine the role of mitogen-activated protein kinases (MAPKs) in hyperic...
The mechanisms of the antineoplastic effect of nonsteroidal anti-inflammatory drugs (NSAIDs) still a...
The p38 mitogen-activated protein kinase (p38MAPK) is activated in response to various stimuli, incl...
Cisplatin is one of the major chemotherapeutic weapons used against different human cancers, althoug...
ABSTRACT The by-product of lipid peroxidation, 4-hydroxynonenal (HNE), was shown to cause apoptosis ...
The stress-activated c-Jun N-terminal protein kinase (JNK) and p38 mitogen-activated protein (MAP) k...
In the present study, we investigated the signaling pathways implicated in the induction of apoptosi...
The aim of the present study was to discover the signaling pathways associated with 2-(3...
TNF-α transduces signals of survival or death via its two receptors, R1/p55/p60 and RII/p80/p75. The...
The role of p38 mitogen-activated protein kinase (MAPK) in apoptosis is a matter of debate. Here, we...
Toll-like receptor (TLR) 2 functions as a sensor for detecting various microbial components conserve...
AbstractA selective p38 MAP kinase (p38 MAPK) inhibitor, SB202190, induced apoptotic cell death of a...
Activation of the mitotic checkpoint by chemotherapeutic drugs such as taxol causes mammalian cells ...
In the present study we examined in more detail the dual role of the c-JUN N-terminal kinase (JNK) a...
Sphingosine induces activation of multiple signaling pathways that play critical roles in controllin...
The present study aims to determine the role of mitogen-activated protein kinases (MAPKs) in hyperic...
The mechanisms of the antineoplastic effect of nonsteroidal anti-inflammatory drugs (NSAIDs) still a...
The p38 mitogen-activated protein kinase (p38MAPK) is activated in response to various stimuli, incl...
Cisplatin is one of the major chemotherapeutic weapons used against different human cancers, althoug...
ABSTRACT The by-product of lipid peroxidation, 4-hydroxynonenal (HNE), was shown to cause apoptosis ...
The stress-activated c-Jun N-terminal protein kinase (JNK) and p38 mitogen-activated protein (MAP) k...