Large-scale molecular annotation of epithelial ovarian cancer (EOC) indicates remarkable heterogeneity in the etiology of that disease. This diversity presents a significant obstacle against intervention target discovery. However, inactivation of miRNA biogenesis is commonly associated with advanced disease. Thus, restoration of miRNA activity may represent a common vulnerability among diverse EOC oncogenotypes. To test this, we employed genome-scale, gain-of-function, miRNA mimic toxicity screens in a large, diverse spectrum of EOC cell lines. We found that all cell lines responded to at least some miRNA mimics, but that the nature of the miRNA mimics provoking a response was highly selective within the panel. These selective toxicity prof...
MicroRNA molecules are small, single-stranded RNA molecules that function to regulate networks of ge...
Purpose: Epithelial ovarian cancer (EOC) is one of the most lethal gynecologic diseases, with surviv...
MicroRNAs (miRNAs) represent a class of small non-coding RNAs that control gene expression by target...
BackgroundThe Cancer Genome Atlas (TCGA) Network recently comprehensively catalogued the molecular a...
Additional contributors: Gang Fang; Michael Steinbach (faculty mentor)Ovarian Cancer is the most let...
Epithelial ovarian cancer (EOC) has a heritable component that remains to be fully characterized. Mo...
Epithelial ovarian cancer (EOC) is a complex disease, with multiple histological subtypes recognized...
MicroRNAs (miRNAs) are an abundant class of small noncoding RNAs that function as negative gene regu...
Serous epithelial ovarian cancer (EOC) patients often succumb to aggressive metastatic disease, yet ...
Epithelial ovarian cancer (EOC) has a heritable component that remains to be fully characterized. Mo...
Ovarian cancer is the fifth most important cause of cancer-related deaths among women and the most...
MicroRNAs are short non-coding RNAs that regulate large suites of target genes. A family of miRNAs ...
Cancer mortality is primarily due to metastasis. Metastasis is a complex multi-step process involvin...
SummaryIntegrated genomic analyses revealed a miRNA-regulatory network that further defined a robust...
Regulation of gene expression is a complex process in mammalian cells with many levels of control. I...
MicroRNA molecules are small, single-stranded RNA molecules that function to regulate networks of ge...
Purpose: Epithelial ovarian cancer (EOC) is one of the most lethal gynecologic diseases, with surviv...
MicroRNAs (miRNAs) represent a class of small non-coding RNAs that control gene expression by target...
BackgroundThe Cancer Genome Atlas (TCGA) Network recently comprehensively catalogued the molecular a...
Additional contributors: Gang Fang; Michael Steinbach (faculty mentor)Ovarian Cancer is the most let...
Epithelial ovarian cancer (EOC) has a heritable component that remains to be fully characterized. Mo...
Epithelial ovarian cancer (EOC) is a complex disease, with multiple histological subtypes recognized...
MicroRNAs (miRNAs) are an abundant class of small noncoding RNAs that function as negative gene regu...
Serous epithelial ovarian cancer (EOC) patients often succumb to aggressive metastatic disease, yet ...
Epithelial ovarian cancer (EOC) has a heritable component that remains to be fully characterized. Mo...
Ovarian cancer is the fifth most important cause of cancer-related deaths among women and the most...
MicroRNAs are short non-coding RNAs that regulate large suites of target genes. A family of miRNAs ...
Cancer mortality is primarily due to metastasis. Metastasis is a complex multi-step process involvin...
SummaryIntegrated genomic analyses revealed a miRNA-regulatory network that further defined a robust...
Regulation of gene expression is a complex process in mammalian cells with many levels of control. I...
MicroRNA molecules are small, single-stranded RNA molecules that function to regulate networks of ge...
Purpose: Epithelial ovarian cancer (EOC) is one of the most lethal gynecologic diseases, with surviv...
MicroRNAs (miRNAs) represent a class of small non-coding RNAs that control gene expression by target...