BACKGROUND: Anaplastic lymphoma receptor tyrosine kinase gene (ALK) fusion is a distinct molecular subclassification of NSCLC that is targeted by anaplastic lymphoma kinase (ALK) inhibitors. We established a transgenic mouse model that expresses tumors highly resembling human NSCLC harboring echinoderm microtubule associated protein like 4 gene (EML)-ALK fusion. We aimed to test an EML4-ALK transgenic mouse model as a platform for assessing the efficacy of ALK inhibitors and examining mechanisms of acquired resistance to ALK inhibitors. METHODS: Transgenic mouse lines harboring LoxP-STOP-LoxP-FLAGS-tagged human EML4-ALK (variant 1) transgene was established by using C57BL/6N mice. The transgenic mouse model with highly lung-specific, induc...
Transgenic mice carrying the activated rat c-neu oncogene under transcriptional control of the MMTV ...
[[abstract]]Background: Recently the echinoderm microtubule-associated protein-like 4-anaplastic lym...
BACKGROUND: The anaplastic lymphoma kinase (ALK) gene is involved frequently in chromosomal transloc...
The echinoderm microtubule-associated protein-like 4 (EML4)-anaplastic lymphoma kinase (ALK) fusion ...
Activation of anaplastic lymphoma receptor tyrosine kinase (ALK) is involved in the pathogenesis of ...
The echinoderm microtubule–associated protein-like 4–anaplastic lymphoma kinase (EML4-ALK) fusion ge...
AbstractThe echinoderm microtubule–associated protein-like 4–anaplastic lymphoma kinase (EML4-ALK) f...
The discovery of an echinoderm microtubule-associated protein-like 4 (EML4)-anaplastic lymphoma kina...
Introduction:The aim of this study was to identify anaplastic lymphoma kinase (ALK) rearrangements i...
It was only 3 years ago that an acquired translocation of EML4 with ALK leading to the expression of...
fusion between the EML4 (echinoderm microtubule-associated protein-like) and ALK (anaplastic lymphom...
Overexpression and activation of TPM3-ALK tyrosine kinase fusion protein is a causal oncogenic event...
International audienceNPM-ALK (nucleophosmin-anaplastic lymphoma kinase) and TPM3-ALK (nonmuscular t...
Background: The echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase (EML4- A...
The anaplastic lymphoma kinase (ALK) gene rearrangement identifies a distinct molecular subset in no...
Transgenic mice carrying the activated rat c-neu oncogene under transcriptional control of the MMTV ...
[[abstract]]Background: Recently the echinoderm microtubule-associated protein-like 4-anaplastic lym...
BACKGROUND: The anaplastic lymphoma kinase (ALK) gene is involved frequently in chromosomal transloc...
The echinoderm microtubule-associated protein-like 4 (EML4)-anaplastic lymphoma kinase (ALK) fusion ...
Activation of anaplastic lymphoma receptor tyrosine kinase (ALK) is involved in the pathogenesis of ...
The echinoderm microtubule–associated protein-like 4–anaplastic lymphoma kinase (EML4-ALK) fusion ge...
AbstractThe echinoderm microtubule–associated protein-like 4–anaplastic lymphoma kinase (EML4-ALK) f...
The discovery of an echinoderm microtubule-associated protein-like 4 (EML4)-anaplastic lymphoma kina...
Introduction:The aim of this study was to identify anaplastic lymphoma kinase (ALK) rearrangements i...
It was only 3 years ago that an acquired translocation of EML4 with ALK leading to the expression of...
fusion between the EML4 (echinoderm microtubule-associated protein-like) and ALK (anaplastic lymphom...
Overexpression and activation of TPM3-ALK tyrosine kinase fusion protein is a causal oncogenic event...
International audienceNPM-ALK (nucleophosmin-anaplastic lymphoma kinase) and TPM3-ALK (nonmuscular t...
Background: The echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase (EML4- A...
The anaplastic lymphoma kinase (ALK) gene rearrangement identifies a distinct molecular subset in no...
Transgenic mice carrying the activated rat c-neu oncogene under transcriptional control of the MMTV ...
[[abstract]]Background: Recently the echinoderm microtubule-associated protein-like 4-anaplastic lym...
BACKGROUND: The anaplastic lymphoma kinase (ALK) gene is involved frequently in chromosomal transloc...