BACKGROUND: Clusterin is a sensitive cellular biosensor of oxidative stress and has been studied as a biomarker for inflammation-associated diseases. Clusterin levels in childhood asthma have not been evaluated. OBJECTIVES: (1) To evaluate sputum clusterin levels in children with asthma compared to a control group. (2) To assess the relationships between sputum clusterin levels and airway inflammation, pulmonary function, and bronchial hyperresponsiveness. METHODS: This study included 170 children aged 5-18 years with stable asthma (n = 91), asthma exacerbation (n = 29), or no asthma (healthy controls; n = 50). Induced sputum, pulmonary function, and methacholine challenge tests were performed. Stable asthma was classified into two groups...
Asthma is a chronic complex disorder of the respiratory tract that affects millions of people global...
Summary: Background: Epidemiological studies have shown an association between the severity of exerc...
Purpose: Exhaled nitric oxide (eNO) has been proposed as a non-invasive marker for airway inflammati...
BACKGROUND: Atopic dermatitis (AD) is a chronic inflammatory skin disease. Clusterin is a sensitive ...
BACKGROUND: Amphiregulin, a member of the epidermal growth factor family, has been shown to promote ...
Background: The monitoring of asthma is based mainly on clinical history, physical examination, and ...
Introduction: The significance of oxidative stress in pathogenesis of childhood asthma was recognize...
BACKGROUND: Cysteinyl-leukotrienes (cys-LTs) and 8-isoprostane are biomarkers of airway inflammation...
Asthma in children and adolescents is a heterogeneous syndrome comprised of multiple poorly-defined ...
STUDY OBJECTIVE: To quantify lung oxidative stress in asthmatic children by measuring concentration...
Purpose: Exercise-induced bronchoconstriction (EIB) affects daily activities as well as school perfo...
CKGROUND: It is recognized that airway inflammation has a central role in the pathogenesis of as...
BACKGROUND: It is recognized that airway inflammation has a central role in the pathogenesis of ast...
BACKGROUND: Recent studies performing fiberoptic bronchoscopy in children have improved our underst...
OBJECTIVE: We aimed to evaluate the association between eosinophilic inflammation in induced sputum ...
Asthma is a chronic complex disorder of the respiratory tract that affects millions of people global...
Summary: Background: Epidemiological studies have shown an association between the severity of exerc...
Purpose: Exhaled nitric oxide (eNO) has been proposed as a non-invasive marker for airway inflammati...
BACKGROUND: Atopic dermatitis (AD) is a chronic inflammatory skin disease. Clusterin is a sensitive ...
BACKGROUND: Amphiregulin, a member of the epidermal growth factor family, has been shown to promote ...
Background: The monitoring of asthma is based mainly on clinical history, physical examination, and ...
Introduction: The significance of oxidative stress in pathogenesis of childhood asthma was recognize...
BACKGROUND: Cysteinyl-leukotrienes (cys-LTs) and 8-isoprostane are biomarkers of airway inflammation...
Asthma in children and adolescents is a heterogeneous syndrome comprised of multiple poorly-defined ...
STUDY OBJECTIVE: To quantify lung oxidative stress in asthmatic children by measuring concentration...
Purpose: Exercise-induced bronchoconstriction (EIB) affects daily activities as well as school perfo...
CKGROUND: It is recognized that airway inflammation has a central role in the pathogenesis of as...
BACKGROUND: It is recognized that airway inflammation has a central role in the pathogenesis of ast...
BACKGROUND: Recent studies performing fiberoptic bronchoscopy in children have improved our underst...
OBJECTIVE: We aimed to evaluate the association between eosinophilic inflammation in induced sputum ...
Asthma is a chronic complex disorder of the respiratory tract that affects millions of people global...
Summary: Background: Epidemiological studies have shown an association between the severity of exerc...
Purpose: Exhaled nitric oxide (eNO) has been proposed as a non-invasive marker for airway inflammati...